Objectives: Micronutrient supplementation in critically ill adults remains controversial. In the pediatric setting, the impact of oxidative stress on the overall micronutrient status has been poorly explored, due to the limited number of studies and to confounding factors (i.e., malnutrition or extra losses). In order to better understand this phenomenon, we aim to describe micronutrient status, focusing on seven micronutrients, in well-nourished critically ill children presenting with severe oxidative stress. Design: Prospective, transversal, observational, single-center study. Setting: PICU, and anesthesiology department, Lyon, France. Patients: Three groups of patients were clinically defined: severe oxidative stress PICU group (at least two organ dysfunctions), moderate oxidative stress PICU group (single organ dysfunction), and healthy control group (prior to elective surgery); oxidative stress intensity was controlled by measuring plasma levels of glutathione peroxidase and glutathione. Children presenting any former condition leading to micronutrient deficiency were excluded (malnutrition, external losses). Interventions: Plasma levels of selenium, zinc, copper, vitamin A, vitamin E, vitamin C, and β-carotene were measured in PICU oxidative stress conditions and compared with those of healthy children. Measurements and Main Results: Two hundred one patients were enrolled (51, 48, and 102 in severe, moderate, and healthy control groups, respectively). Median age was 7.1 years (interquartile range, 2.1–13.8 yr). There was a significant trend (p
from Emergency Medicine via xlomafota13 on Inoreader https://ift.tt/2I31eo5
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Publication date: Available online 7 July 2018 Source: The Journal of Emergency Medicine Author(s): Audrey Uong, Ariel Brandwein, Colin C...
-
Oral Candida colonization in xerostomic post‐radiotherapy head and neck cancer patients 16h ... Oral Candida colonization in xerostomic post...
-
Abstract Malignant brain tumors are rapidly progressive and often fatal owing to resistance to therapies and based on their complex biolog...
-
Abstract Background Bone flap resorption (BFR) is the most prevalent complication resulting in autologous cranioplasty failure, but no c...
-
Injury from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1ULgTKC
-
Abstract Objectives Tumor invasion into blood and/or lymphatic vessels, perineural invasion, and histopathological grading are evaluated...
-
Objectives: Pantoprazole is frequently administered to critically ill patients for prophylaxis against gastrointestinal bleeding. However, ...
-
Abstract Non-tumoral portal vein thrombosis (PVT) remains a highly relevant topic in the field of hepatology and liver transplantation wit...
-
Abstract Many methods exist for generating keyframe summaries of videos. However, relatively few methods consider on-line summarisation, w...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου