The effects of cryopreserved red blood cell transfusion on tissue oxygenation in obese trauma patients.

Background: Low tissue oxygenation (StO2) is associated with poor outcomes in obese trauma patients. A novel treatment could be the transfusion of cryopreserved packed red blood cells (CPRBCs), which the in vitro biochemical profile favors RBC function. We hypothesized that CPRBC transfusion improves StO2 in obese trauma patients. Methods: 243 trauma patients at five Level 1 trauma centers who required RBC transfusion were randomized to receive 1-2 units of liquid PRBCs (LPRBCs) or CPRBCs. Demographics, injury severity, StO2, outcomes, and biomarkers of RBC function were compared in non-obese (BMI=30) patients. StO2 was also compared between obese patients with BMI of 30-34.9 and BMI>=35. StO2 was normalized and expressed as % change following RBC transfusion. p=30, (n=102) had similar ISS, GCS, and baseline StO2. Plasma levels of free hemoglobin, an index of RBC lysis, were lower in obese patients following CPRBC (125 (72-259) [mu]g/ml) versus LPRBC transfusion (230 (178-388) [mu]g/ml; p=35, starting 5hrs following transfusion (p

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