Two-site regional oxygen saturation and capnography monitoring during resuscitation after cardiac arrest in a swine pediatric ventricular fibrillatory arrest model

Abstarct

To investigate the use of two-site regional oxygen saturations (rSO₂) and end tidal carbon dioxide (EtCO₂) to assess the effectiveness of resuscitation and return of spontaneous circulation (ROSC). Eight mechanically ventilated juvenile swine underwent 28 ventricular fibrillatory arrests with open cardiac massage. Cardiac massage was administered to achieve target pulmonary blood flow (PBF) as a percentage of pre-cardiac arrest baseline. Non-invasive data, including, EtCO₂, cerebral rSO₂ (C-rSO₂) and renal rSO₂ (R-rSO₂) were collected continuously. Our data demonstrate the ability to measure both rSO₂ and EtCO₂ during CPR and after ROSC. During resuscitation EtCO₂ had a strong correlation with goal CO with r = 0.83 (p < 0.001) 95% CI [0.67–0.92]. Both C-rSO₂ and R-rSO₂ had moderate and statistically significant correlation with CO with r = 0.52 (p = 0.003) 95% CI (0.19–0.74) and 0.50 (p = 0.004) 95% CI [0.16–0.73]. The AUCs for sudden increase of EtCO₂, C-rSO₂, and R-rSO₂ at ROSC were 0.86 [95% CI, 0.77–0.94], 0.87 [95% CI, 0.8–0.94], and 0.98 [95% CI, 0.96–1.00] respectively. Measurement of continuous EtCO₂ and rSO₂ may be used during CPR to ensure effective chest compressions. Moreover, both rSO₂ and EtCO₂ may be used to detect ROSC in a swine pediatric ventricular fibrillatory arrest model.

https://ift.tt/2XwXLHg