Objectives: No double-blinded clinical trials have investigated optimal mean arterial pressure targets in the ICU. The aim of this study was to develop and validate a method for blinded investigation of mean arterial pressure targets in patients monitored with arterial catheter in the ICU. Design: Prospective observational study (substudy A) and prospective, randomized, controlled clinical study (substudy B). Setting: ICU, Department of Cardiology, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark. Patients: Adult patients resuscitated from out-of-hospital cardiac arrest. Interventions: Standard blood pressure measuring modules were offset to display 10% lower or higher blood pressure values. We then: 1) confirmed this modification in vivo by comparing offset to standard modules in 22 patients admitted to the ICU. Thereafter we 2) verified the method in two randomized, clinical trials, each including 50 out-of-hospital cardiac arrest patients, where the offset of the blood pressure module was blinded to the treating staff. Measurements and Main Results: Substudy A showed that the expected separation of blood pressure measurements was achieved with an excellent correlation of the offset and standard modules (R2 = 0.997). Bland-Altman plots showed no bias of modified modules over a clinically relevant range of mean arterial pressure. The primary endpoint of the clinical trials was between-group difference of norepinephrine dose needed to achieve target mean arterial pressure. Trial 1 aimed at a 10% difference between groups in mean arterial pressure (targets: 65 and 72 mm Hg, respectively) and demonstrated a separation of 5 ± 1 mm Hg (p
from Emergency Medicine via xlomafota13 on Inoreader https://ift.tt/2uoJChJ
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Abstract Introduction In recent years, platelet-rich plasma (PRP) has emerged as a promising autologous biological treatment modality fo...
-
Long non-coding RNA RP11-6O2.4 indicates poor prognosis and suppresses cell cycle progression through the p38-MAPK signaling pathway in gast...
-
BMC Neurology Towards seeing the visual impairments in Parkinson's disease: protocol for a multicentre observational, cross-sectional st...
-
Learn how to recognize the signs of sudden cardiac arrest and to administer CPR in less than 5 minutes. from EMS via xlomafota13 on Inorea...
-
Publication date: July 2018 Source: The Journal of Emergency Medicine, Volume 55, Issue 1 Author(s): Heather Roesly from Emergency Med...
-
68 JOURNALS 1afcn2-ucoco.htmlAccepted Articles Alert_ British Journal of Dermatology.eml 2ar15h-49goz.htmlAccepted Articles Alert_ Clinical ...
-
The American Journal of Emergency Medicine from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2fpeT0d
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου