Objectives: To assess the prevalence of central line–associated bloodstream infections in pediatric patients with and without chylothorax after cardiac surgery and identify risk factors that predict those patients at highest risk for developing a central line–associated bloodstream infection. Design: Retrospective single-center cohort study. Setting: A PICU located within a tertiary-care academic pediatric hospital. Patients: All pediatric patients admitted to the PICU after cardiac surgery between 2008 and 2014. Interventions: None. Measurements and Main Results: We identified 1,191 pediatric cardiac surgery patients in the study time frame, of which 66 (5.5%) had chylothorax. Patients with chylothorax were more likely to have a central line–associated bloodstream infection (23% vs 3.8%; p
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