Background *: Despite limited data regarding the indications and effectiveness of percutaneous cholecystostomy (PC) in the treatment of acute cholecystitis (AC), usage has increased by over 500% since 1994. Many of these patients subsequently undergo interval cholecystectomy (IC), a procedure that has not been rigorously evaluated. This aim of this study was to quantify the morbidity and mortality associated with the IC. Methods *: We included all consecutive adult patients (>18 years old) who underwent PC and IC from January 2008 to December 2013. Conversion rate, length of operation, biliary injury, estimated blood loss, surgical site infection, length of stay, and mortality were compared to 227 patients who underwent cholecystectomy for acute cholecystitis during the same time interval. Results *: Of 18,501 patients who underwent cholecystectomy, 337 had at least one PC and 177 underwent subsequent IC. Compared to patients undergoing cholecystectomy for clinically diagnosed AC, patients undergoing IC were older (69.8 v 54.9 years, p
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