Intraoperative hypotensive resuscitation for patients undergoing laparotomy or thoracotomy for trauma: Early termination of a randomized prospective clinical trial.

Background: Hemorrhagic shock is responsible for one-third of trauma related deaths. We hypothesized intraoperative hypotensive resuscitation would improve survival for patients undergoing operative control of hemorrhage following penetrating trauma. Methods: Between July 1, 2007 and March 28, 2013 penetrating trauma patients aged 14-45 with a systolic blood pressure 0.05 for all. Acute renal injury occurred less often in the LMAP than HMAP group (13% vs 30%, p=0.01). Conclusion: This study was unable to demonstrate that hypotensive resuscitation at a target MAP of 50 mmHg could significantly improve 30-day mortality. Further study is necessary to fully realize the benefits of hypotensive resuscitation. Level of Evidence Level II, Therapeutic/Care Management (C) 2016 Lippincott Williams & Wilkins, Inc.

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