INTRODUCTION: Motor vehicle crashes are the leading cause of death and nonfatal injury among young adults. The aim of this study was to assess the magnitude of distracted driving (DD) among students and to examine the effectiveness of awareness campaign against DD. We hypothesized that DD is prevalent among students and educational efforts such as distracted driving awareness campaign can effectively reduce it. METHODS: This study was conducted within the University of Arizona that has a student enrollment of 42,000 students. We conducted our prospective interventional study in four phases at the University campus. Phase one: 1 week pre-intervention observation, phase two: 1 week intervention, phase three: 1 week post-intervention observation, and phase 4: 1 week 6 month post-intervention observation. We used a combination of emails, pamphlets, interactive sessions, and banners as intervention tools in student union. Our primary outcome was the prevalence of DD pre, post, and 6 months post intervention. RESULTS: A total of 47,764 observations (Pre: 14,844, Post: 17,939, 6-months Post: 14,981) were performed. During the study period, overall rate of distracted driving rate among the students was 8.8+/-5.4 per 100 drivers (Texting; 4.8+/-3.7 per 100 drivers, Talking; 3.9+/-2.0 per 100 drivers). The baseline rate of DD among students during the phase one was 9.0 +/- 1.2 per 100 drivers (Texting: 4.8 +/- 1.7 per 100 drivers, Talking: 4.1 +/- 1.1 per 100 drivers). Following intervention, there was a 32% significant reduction in overall DD (9.0 +/- 1.2 vs. 6.1 +/- 1.7, p
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