Clearance of Indocyanine Green in Severe Pediatric Burns

Background Clearance of indocyanine green dye (ICGc) reflects sinusoidal perfusion and hepatocyte cell membrane function. Thus, ICGc is a reflection of the functional reserve of intact hepatocytes. The purpose of this study was to identify predictors of ICGc in severely burned children during the acute hospitalization and at the time of discharge from the ICU. A secondary aim was to determine the relationship between liver size and patient ICGc. Methods Twenty-six children (0.8 to 17 years old) with 35% or greater total body surface area burned (%TBSA-B) were included. Assessment of ICGc (ml·min-1·m-2) was done during the acute hospitalization (Median: 6 days after admission, Median: 14 days post-burn) and at the time of discharge from the ICU (Median: 19 days after admission, Median: 27 days post-burn). Age, TBSA-B, % third degree burns, inhalation injury, pre-existing chronic malnutrition, hematocrit, liver dysfunction, and time from burn injury were incorporated in multiple linear regressions as predictive variables of ICGc. Only variables with p

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