Objectives: To determine and quantify risk factors for postoperative pediatric delirium. Design: Single-center prospective cohort study. Setting: Twenty-two bed PICU in a tertiary care academic medical center in Germany. Patients: All children admitted after major elective surgery (n = 93; 0–17 yr). Interventions: After awakening, children were screened for delirium using the Cornell Assessment of Pediatric Delirium bid over a period of 5 days. Demographic and clinical data were collected from the initiation of general anesthesia. Measurements and Main Results: A total of 61 patients (66%) were delirious. Younger children developed delirium more frequently, and the symptoms were more pronounced. The number of preceding operations did not influence the risk of delirium. Total IV anesthesia had a lower risk than inhalational anesthesia (p
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