Objectives: To evaluate the effectiveness and safety of a family-centered care intervention in a Chinese neonatal ICU. Design: Pilot study using a randomized controlled trial design to inform a main randomized controlled trial study. Setting: Stand-alone tertiary children’s hospital in China with a 60-bed neonatal ICU serving as a regional neonatal ICU center. Patients: Premature infants (n = 61) and their parents (n = 110). Interventions: Parent education program followed by parents’ participation in care as primary caregiver until discharge for a minimum of 4 hours per day. Measurements and Main Results: Primary outcomes were infants’ weight gain at discharge, length of stay, and readmission. Parental outcomes were stress, anxiety, satisfaction, and clinical knowledge. Infants in family-centered care group (n = 31) had higher weight gain (886g vs 542g; p = 0.013), less neonatal ICU length of stay in days (43 vs 46; p = 0.937), and decreased readmission rate at 1 week (41.9 vs 70.0; p = 0.045) and at 1 month (6.5% vs 50%; p
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