In Vitro Effects of a Kaolin Coated Hemostatic Dressing on Anticoagulated Blood

Background The use of kaolin coated dressings has become common and have efficacy in normal patients, but their increased use will inevitably include use on bleeding patients taking anticoagulants. We hypothesize that kaolin coating material (KCM) will improve clotting regardless of anticoagulation medication. Methods A prospective study was performed on blood from patients who were on on a vitamin K antagonist (VKA), unfractionated heparin (UH), an anti-platelet (AP) agent, a Xa inhibitor (Xa), or a direct thrombin inhibitor (DTI). None were on more than one type of anticoagulation medication. Viscoelastic testing was performed with and without KCM. All p-values were adjusted for multiple comparisons. Results The addition of KCM significantly decreased the time for initial clot formation (CT) in all groups. The mean CT for controls was decreased from 692 to 190.8 sec(p

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