Objectives: Acute kidney injury is a serious complication with unacceptably high mortality that lacks of specific curative treatment. Therapies focusing on the hydraulic behavior have shown promising results in preventing structural and functional renal impairment, but the underlying mechanisms remain understudied. Our goal is to assess the effects of renal decapsulation on regional hemodynamics, oxygenation, and perfusion in an ischemic acute kidney injury experimental model. Methods: In piglets, intra renal pressure, renal tissue oxygen pressure, and dysoxia markers were measured in an ischemia-reperfusion group with intact kidney, an ischemia-reperfusion group where the kidney capsule was removed, and in a sham group. Results: Decapsulated kidneys displayed an effective reduction of intra renal pressure, an increment of renal tissue oxygen pressure, and a better performance in the regional delivery, consumption, and extraction of oxygen after reperfusion, resulting in a marked attenuation of acute kidney injury progression due to reduced structural damage and improved renal function. Conclusions: Our results strongly suggest that renal decapsulation prevents the onset of an intrinsic renal compartment syndrome after ischemic acute kidney injury. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (http://ift.tt/29S62lw). Drs. Cruces, Salas, and F. Lillo received support for article research from the Sociedad Chilena de Pediatria. The remaining authors have disclosed that they do not have any potential conflicts of interest. Supported, in part, by the Fondecyt Regular number 1160631 grant of the Fondo Nacional de Desarrollo Científico y Tecnológico, the Proyecto en Ciencias Biomédicas y Clínicas 2015 Universidad Andrés Bello (DI-749-15/CB), and by funding from the Sociedad Chilena de Pediatría 2012001 Grant. For information regarding this article, E-mail: dhurtado@ing.puc.cl Copyright © by 2017 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.
from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2zxzOUX
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Abstract Introduction In recent years, platelet-rich plasma (PRP) has emerged as a promising autologous biological treatment modality fo...
-
What is the future made of ? ( Hint: "Free" Healt-Care from pregnancy - Grave. "Free" Edukation, From pre school to uni...
-
Learn the basics on how to use the Emergency Response Guidebook (ERG). from EMS via xlomafota13 on Inoreader http://ift.tt/2wMDm75
-
If a disaster hits your community, will you be prepared? Are your leaders asking the right questions and taking the right steps to make sur...
-
Abstract This article on alternative markers of performance in simulation is the product of a session held during the 2017 Academic Emerge...
-
Healthcare Finance News from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2xx5f3c
-
Learn how to recognize the signs of sudden cardiac arrest and to administer CPR in less than 5 minutes. from EMS via xlomafota13 on Inorea...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου