Objectives: Recent transcriptomic studies describe two subgroups of adults with sepsis differentiated by a sepsis response signature. The implied biology and related clinical associations are comparable with recently reported pediatric sepsis endotypes, labeled “A” and “B.” We classified adults with sepsis using the pediatric endotyping strategy and the sepsis response signature and determined how endotype assignment, sepsis response signature membership, and age interact with respect to mortality. Design: Retrospective analysis of publically available transcriptomic data representing critically ill adults with sepsis from which the sepsis response signature groups were derived and validated. Setting: Multiple ICUs. Patients: Adults with sepsis. Interventions: None. Measurements and Main Results: Transcriptomic data were conormalized into a single dataset yielding 549 unique cases with sepsis response signature assignments. Each subject was assigned to endotype A or B using the expression data for the 100 endotyping genes. There were 163 subjects (30%) assigned to endotype A and 386 to endotype B. There was a weak, positive correlation between endotype assignment and sepsis response signature membership. Mortality rates were similar between patients assigned endotype A and those assigned endotype B. A multivariable logistic regression model fit to endotype assignment, sepsis response signature membership, age, and the respective two-way interactions revealed that endotype A, sepsis response signature 1 membership, older age, and the interactions between them were associated with mortality. Subjects coassigned to endotype A, and sepsis response signature 1 had the highest mortality. Conclusions: Combining the pediatric endotyping strategy with sepsis response signature membership might provide complementary, age-dependent, biological, and prognostic information.
from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2AQWVsQ
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Zusammenfassung Hintergrund Die Störung der Blut-Hirn-Schranke – gemessen mittels Magnetresonanztomographie – stellt kein zuverlässiges ...
-
Video from Norwegian TAS3 training-Rapid Extraction: From N.Z. ..: "The whole front of the car had been ripped away on impact of the cr...
-
Morbidity and Mortality Weekly Report from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/22oQ5mB
-
# ** Family Owned Business Since 1962- Always Hiring Great People** ### Wage:$12.02-$13.27 per hour #### Salary & Benefits\*: $43,048-$4...
-
from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2EdTCxV
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου