Hypoxemic Patients With Bilateral Infiltrates Treated With High-Flow Nasal Cannula Present a Similar Pattern of Biomarkers of Inflammation and Injury to Acute Respiratory Distress Syndrome Patients.

Objective: To examine whether patients with acute hypoxemia and bilateral opacities treated with high-flow nasal cannula and acute respiratory distress syndrome patients who were directly mechanically ventilated are similar in terms of lung epithelial, endothelial, and inflammatory biomarkers. Design: Prospective, multicenter study. Setting: ICUs at three university tertiary hospitals. Patients: Intubated and nonintubated patients admitted to the ICU with acute hypoxemia (PaO2/FIO2

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