Objectives: High-dose valproic acid in combination with hypothermic-targeted temperature management has been reported to synergistically improve neurologic outcomes after cardiac arrest. This study investigated the potential synergistic mechanisms. Design: Prospective, randomized, experimental study. Setting: University research institution. Subjects: Male Long Evans rats. Intervention: Rats resuscitated from asphyxial cardiac arrest were randomized to one of the three groups: normothermic-targeted temperature management (37[degrees]C +/- 1[degrees]C), hypothermic-targeted temperature management (33[degrees] +/- 1[degrees] x 24 hr + placebo infusion), hypothermic-targeted temperature management plus high-dose valproic acid (300 mg/kg IV x 1 initiated 5 min post return of spontaneous circulation and infused over 20 min) (hypothermic-targeted temperature management + valproic acid). Measurements and Main Results: Seventy-two-hour survival was significantly greater with hypothermic-targeted temperature management + valproic acid, compared to hypothermic-targeted temperature management and normothermic-targeted temperature management (p
from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2gp5PZK
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Oral Candida colonization in xerostomic post‐radiotherapy head and neck cancer patients 16h ... Oral Candida colonization in xerostomic post...
-
Hard to believe, but there was a time we were without the most necessary EMS tools. That all changed, thanks to these creative minds. fro...
-
U.S. Department of Veterans Affairs Research News from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2iVEnBB
-
Clinical application of stress echocardiography for valvular heart disease Abstract Stress echocardiography is widely used to assess several...
-
MedStar replaced training diagrams with drone flyovers of the driving course to better demonstrate how to navigate a complicated driving sc...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου