Abstract
To better understand epidemiology of SARS-CoV-2 reinfections, we analyzed national data from South Korea n who were followed longitudinally from January 2020 to April 2022. We conducted a nationwide retrospective cohort study to estimate possible SARS-CoV-2 reinfection rates in all residents in South Korea, with at least two episodes of laboratory-confirmed SARS-CoV-2 infection by reverse-transcriptase polymerase chain reaction (RT-PCR) or rapid antigen test (RAT) performed at least 45 or more days between both episodes, between January 2020 and April 2022. There were 1,6130,855 laboratory-confirmed SARS-CoV-2 cases in South Korea, with 55,841 (346.2 per 100,000; or 0.3% of all infections) were cases of possible reinfections. Reinfection rate has increased from 6.0 cases per 100,000 during Pre-Delta period to 128.0 cases per 100,000 and 355.1 cases per 100,000 during Delta and Omicron periods, respectively. Persons with one dose of vaccination had the highes t reinfection rate of 642.2 per 100,000, followed by unvaccinated persons (536.2/100,000) and two-dose vaccinated persons (406.3/100,000). Our finding suggests the majority of possible reinfections occurred following emergence of new variants.
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