Objectives: Evaluate trends in method of access (percutaneous cannulation vs open cannulation) for pediatric extracorporeal membrane oxygenation and determine the effects of cannulation method on morbidity and mortality. Design: Retrospective cohort study. Setting and Subjects: The Extracorporeal Life Support Organization’s registry was queried for pediatric patients on extracorporeal membrane oxygenation for respiratory failure from 2007 to 2015. Inverventions: None. Measurements and Main Results: Of 3,501 patients identified, 77.2% underwent open cannulation, with the frequency of open cannulation decreasing over the study period from approximately 80% to 70% (p
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