Hepcidin and Anemia in Surgical Critical Care: A Prospective Cohort Study

Objective: Because anemia of inflammation is common in ICU patients and hepcidin is the key regulator of iron homeostasis, we examined time-dependent changes in hepcidin, erythropoietin, iron, and inflammatory markers in surgical ICU patients with anemia. Design: Prospective single-center clinical noninterventional study. Setting: Surgical ICUs; U.S. university hospital. Patients: One hundred surgical adult ICU patients. Measurements and Main Results: Time-dependent changes in serum hepcidin, hematologic, and erythropoietic studies were performed on ICU admission and at serial time-points through day 28, and correlated with hematologic and iron parameters and inflammatory response. Median serum hepcidin levels were significantly increased at ICU admission and decreased over time (144–36 ng/mL; p

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