Objective: To determine the optimal endotracheal tube insertion depth in extremely low-birth-weight infants based on the association between endotracheal tube depth and gestational age, body weight, body length, and head and chest circumferences at birth. Design: Retrospective chart review. Setting: Neonatal ICU at a medical center. Patients: Fifty-two hospitalized extremely low-birth-weight infants in our neonatal ICU. Interventions: None. Measurements and Main Results: Data regarding gestational age, body weight, body length (crown–heel length), head and chest circumferences, and final endotracheal tube depth were retrieved from the medical records of 52 newborn infants weighing less than or equal to 1,000 g at birth (boys, 29; girls, 23). The mean gestational age was 25.1 (range, 22–32) weeks, and the mean body weight was 724.5 (range, 400–1,000) g. Of the endotracheal tubes used, 3%, 87%, and 10% of endotracheal tubes were of size 2.0, 2.5, and 3.0, respectively. Linear regression analysis revealed a significant association between endotracheal tube depth and gestational age, body weight, body length, head, and chest circumferences (p
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