Τετάρτη 31 Ιανουαρίου 2018

Implementation of a Novel Algorithm to Decrease Unnecessary Hospitalizations in Patients Presenting to a Community Emergency Department with Atrial Fibrillation

Abstract

Objectives

Atrial fibrillation (AFib) is the most common dysrhythmia in the United States. Patients seen in the emergency department (ED) in rapid AFib are often started on intravenous rate controlling agents and admitted for several days. Although underlying and triggering illnesses must be addressed, AFib, intrinsically, is rarely life threatening and can often be safely managed in an outpatient setting. At our academic community hospital, we implemented an algorithm to decrease hospital admissions for individuals presenting with a primary diagnosis of AFib. We focused on lenient oral rate control and discharge home. Our study evaluates outcomes after implementation of this algorithm.

Methods

Study design is a retrospective cohort analysis pre and post implementation of the algorithm. The primary outcome was hospital admissions. Secondary outcomes were 3-day and 30-day ED visits and any associated hospital admissions. These outcomes were compared before (March 2013-February 2014) and after (March 2015-February 2016) implementation. Chi-square tests and logistic regressions were run to test for significant changes in the three outcome variables.

Results

A total of 1,108 individuals met inclusion criteria with 586 patients in the pre-implementation group and 522 in the post-implementation group. Cohorts were broadly comparable in terms of demographics and health histories. Admissions for persons presenting with AFib after implementation decreased significantly (80.4% pre vs 67.4% post, adjusted OR = 3.4, P < .001). Despite this difference there was no change in ED return rates within 3 or 30 days, adjusted ORs = 0.93 and 0.89, P = .91 and .73, respectively.

Conclusions

Implementation of a novel algorithm to identify and treat low-risk patients with AFib can significantly decrease the rate of hospital admissions without increased emergency department returns. This simple algorithm could be adopted by other community hospitals and help lower costs.

This article is protected by copyright. All rights reserved.



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Epidemiology, causes, evolution and outcome in a single-center cohort of 1116 critically ill patients with hypoxic hepatitis

Hypoxic hepatitis (HH) is a type of acute hepatic injury that is histologically characterized by centrilobular liver cell necrosis and that is caused by insufficient oxygen delivery to the hepatocytes. Typical...

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Hemoglobin Levels Across the Pediatric Critical Care Spectrum: A Point Prevalence Study

Objectives: To determine the prevailing hemoglobin levels in PICU patients, and any potential correlates. Design: Post hoc analysis of prospective multicenter observational data. Settings: Fifty-nine PICUs in seven countries. Patients: PICU patients on four specific days in 2012. Interventions: None. Measurements and Main Results: Patients’ hemoglobin and other clinical and institutional data. Two thousand three hundred eighty-nine patients with median age of 1.9 years (interquartile range, 0.3–9.8 yr), weight 11.5 kg (interquartile range, 5.4–29.6 kg), and preceding PICU stay of 4.0 days (interquartile range, 1.0–13.0 d). Their median hemoglobin was 11.0 g/dL (interquartile range, 9.6–12.5 g/dL). The prevalence of transfusion in the 24 hours preceding data collection was 14.2%. Neonates had the highest hemoglobin at 13.1 g/dL (interquartile range, 11.2–15.0 g/dL) compared with other age groups (p

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Τρίτη 30 Ιανουαρίου 2018

Reliability of respiratory pressure measurements in ventilated and non-ventilated patients in ICU: an observational study

Assessment of maximum respiratory pressures is a common practice in intensive care because it can predict the success of weaning from ventilation. However, the reliability of measurements through an intubation...

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Déjà vu

Abstract

“Respiratory distress. Four minutes out” crackled the radio. Terrified, I walked over to the resuscitation bay. It was my third day as an intern. An elderly man came in puffing away on BiPAP. His frail chest heaved about forty times a minute. My chief resident nudged me to the head of the bed, and told me to get set to intubate.

This article is protected by copyright. All rights reserved.



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A comparison of care delivered in hospital-based and freestanding emergency departments

Abstract

Objective

We compare case-mix, hospitalization rates, length of stay (LOS), and resource use in independent freestanding emergency departments (FSEDs) and hospital-based emergency departments (H-EDs).

Methods

Data from 74 FSEDs (2013-5) in Texas and Colorado, were compared to H-ED data from the 2013-14 National Hospital Ambulatory Medical Care Survey. In the unrestricted sample, large differences in visit characteristics (e.g. payer and case mix) were found between patients that use FSEDs compared to H-EDs. Therefore, we restricted our analysis to patients commonly treated in both settings (<65 years, privately insured, non-ambulance) and used inverse propensity score weighting (IPW) to balance the two settings on observable patient characteristics. We then compared ED length of stay and as well as hospital admission rates and resource utilization rates in the IPW-weighted samples.

Results

Before balancing, FSEDs saw more young adults (age 25-44), and fewer older adults (age 45-64) than H-EDs. FSED patients had fewer comorbidities, more injuries and respiratory infections, and fewer diagnoses of chest or abdominal pain. In balanced samples, LOS for FSED visits was 46% shorter (60 minutes) than H-ED patients. Hospital admission rates were 37% lower overall (95% CI -51%, -23%) in FSEDs and varied considerably by primary discharge diagnosis. X-ray and EKG use was significantly lower at FSEDs while others measures of resource utilization were similar (ultrasound, CT scans and laboratory tests).

Conclusion

In this sample of FSEDs, a greater proportion of younger patients with fewer comorbidities and more injuries and respiratory system diseases were evaluated, and almost all patients had private health insurance. When restricted to <65, privately insured, and non-ambulance patients in both samples, LOS was considerably shorter and hospital admission rates lower at FSEDs, as well as the use of some diagnostic testing. This study is limited as diagnoses codes may not fully capture severity and patients who perceived greater need of hospital admission may have chosen a H-ED over FSEDs.

This article is protected by copyright. All rights reserved.



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Δευτέρα 29 Ιανουαρίου 2018

Sensemaking in the formation of basic life support teams - a proof-of-concept, qualitative study of simulated in-hospital cardiac arrests

The formation of critical care teams is a complex process where team members need to get a shared understanding of a serious situation. No previous studies have focused on how this shared understanding is achi...

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Favorite Features of Elite for EMS & Fire

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ImageTrend Elite™ offers both EMS and fire incident documentation on a single platform. Elite also has many other distinct advantages for more efficient workflow, department operations management and data analysis. In this video, Phil provides an overview of some of the favorite features of Elite for EMS and Fire. Fully NEMSIS v3 Compliant (Collect and Receive & Process), NFIRS 5.0 compliant, platform independent, cloud-based and offline/online capable ePCR and fire RMS.

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PulmCrit- Metabolic sepsis resuscitation: Strike hard, strike fast, no remorse

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Escalation-deescalation There are roughly two strategies for adjusting the intensity of treatment: Titrated strategy: Treatment intensity is adjusted to match the severity of the disease. Escalation-deescalation strategy: Treatment intensity is increased rapidly to exceed disease severity and gain control of the disease.  After the patient improves, treatment intensity is reduced. The best strategy depends on […]

EMCrit Project by Josh Farkas.



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PulmCrit- Metabolic sepsis resuscitation: Strike hard, strike fast, no remorse

opener75.jpg?resize=1000%2C478&ssl=1

Escalation-deescalation There are roughly two strategies for adjusting the intensity of treatment: Titrated strategy: Treatment intensity is adjusted to match the severity of the disease. Escalation-deescalation strategy: Treatment intensity is increased rapidly to exceed disease severity and gain control of the disease.  After the patient improves, treatment intensity is reduced. The best strategy depends on […]

EMCrit Project by Josh Farkas.



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Κυριακή 28 Ιανουαρίου 2018

When CPR Doesn't Work

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<p style="margin-bottom: 1.2em;">CPR is an attempt to make up for circulation in the heart that is not happening normally. CPR does not stop the dying process; it simply slows down biological cell death. The hope is that this procedure can buy time for EMS to arrive to try other methods of restoring proper circulation of oxygenated blood throughout the body to buy even more time so that the underlying reason why the person went into cardiac arrest in the first place can be explored. If CPR doesn't work, remember, you gave that person that best chance of survival.</p> <p style="font-size: 1.2em; font-weight: bold; margin-bottom: 1.2em;">Visit ProCPR for comprehensive <a href="http://www.procpr.org/training">CPR and first aid training</a>.</p>

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How to Administer Narcan for Opioid Overdose

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<p style="margin-bottom: 1.2em;">Opiates and opioids are central nervous system depressants and their use can lead to overdose. Overdose commonly occurs when the patient takes more than prescribed, when the opioids are combined with other drugs, or when the person has a condition that makes them more sensitive to overdose.</p> <p style="margin-bottom: 1.2em;">There are several kinds of opiates and opioids whose effects can be reversed with proper administration of Naloxone Intramuscular or Intranasal, also known as Narcan.</p> <p style="font-size: 1.2em; font-weight: bold; margin-bottom: 1.2em;">Visit ProCPR for comprehensive <a href="http://www.procpr.org/training">CPR and first aid training</a>.</p>

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How to Administer Narcan for Opioid Overdose

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Opiates and opioids are central nervous system depressants and their use can lead to opiate or opioid overdose. Overdose commonly occurs when the patient takes more than prescribed, when the opioids are combined with other drugs, or when the person has a condition that makes them more sensitive to overdose. There are several kinds of opiates and opioids whose effects can be reversed with proper administration of Naloxone Intramuscular or Intranasal, also known as Narcan.

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Σάββατο 27 Ιανουαρίου 2018

CC Nerd-The Case of the Inverted Premise

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No mode of ventilation is burdened with more emotional baggage than airway pressure release ventilation (APRV). The mere suggestion of its use is met with either the delight of recognizing an old friend whom you are meeting for the first time, or the type of disgust typically reserved for the likes of snake oil salesmen. […]

EMCrit Project by Rory Spiegel.



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CC Nerd-The Case of the Inverted Premise

The-Case-of-the-Inverted-Assumptions.jpg

No mode of ventilation is burdened with more emotional baggage than airway pressure release ventilation (APRV). The mere suggestion of its use is met with either the delight of recognizing an old friend whom you are meeting for the first time, or the type of disgust typically reserved for the likes of snake oil salesmen. […]

EMCrit Project by Rory Spiegel.



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Παρασκευή 26 Ιανουαρίου 2018

NEW ORALITE V98 Pre-Striped Chevron

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Steve Plomin, Vehicle Conspicuity Market Manager, introduces new ORALITE V98 Pre-Striped Chevron material. Designed for emergency vehicles, save time and money with the advantage of a pre-printed chevron.

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ORAFOL Americas Fire Trim Demo

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See the difference between our prismatic fire trim and traditional glass bead trim. Our fire trim works when wet. Does yours?

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NEW ORALITE V98 Pre-Striped Chevron

maxresdefault.jpg

Steve Plomin, Vehicle Conspicuity Market Manager, introduces new ORALITE V98 Pre-Striped Chevron material. Designed for emergency vehicles, save time and money with the advantage of a pre-printed chevron.

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ORAFOL Americas Fire Trim Demo

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See the difference between our prismatic fire trim and traditional glass bead trim. Our fire trim works when wet. Does yours?

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Man saved by EMT as baby becomes first responder

By EMS1 Staff NEW YORK — A man who was saved by an EMT when he was born a premature baby reunited with him as he graduated from the EMS academy himself. NY Post reported that Joseph Bitetto reunited with EMT-turned NYPD detective Howard Blanck 22 years later as he walked across the stage during FDNY’s EMS graduation. Bitetto’s mom suffered a ruptured placenta in 1996 when she was just ...

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NEW ORALITE V98 Pre-Striped Chevron

maxresdefault.jpg

Steve Plomin, Vehicle Conspicuity Market Manager, introduces new ORALITE V98 Pre-Striped Chevron material. Designed for emergency vehicles, save time and money with the advantage of a pre-printed chevron.

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ORAFOL Americas Fire Trim Demo

maxresdefault.jpg

See the difference between our prismatic fire trim and traditional glass bead trim. Our fire trim works when wet. Does yours?

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NEW ORALITE V98 Pre-Striped Chevron

maxresdefault.jpg

Steve Plomin, Vehicle Conspicuity Market Manager, introduces new ORALITE V98 Pre-Striped Chevron material. Designed for emergency vehicles, save time and money with the advantage of a pre-printed chevron.

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ORAFOL Americas Fire Trim Demo

maxresdefault.jpg

See the difference between our prismatic fire trim and traditional glass bead trim. Our fire trim works when wet. Does yours?

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Man who was saved by EMT as a baby becomes first responder

By EMS1 Staff NEW YORK — A man who was saved by an EMT when he was born a premature baby reunited with him as he graduated from the EMS academy himself. NY Post reported that Joseph Bitetto reunited with EMT-turned NYPD detective Howard Blanck 22 years later as he walked across the stage during FDNY’s EMS graduation. Bitetto’s mom suffered a ruptured placenta in 1996 when she was just ...

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Sepsis-Associated Coagulopathy Severity Predicts Hospital Mortality

Objectives: To assess whether sepsis-associated coagulopathy predicts hospital mortality. Design: Retrospective cohort study. Setting: One-thousand three-hundred beds urban academic medical center. Patients: Six-thousand one-hundred forty-eight consecutive patients hospitalized between January 1, 2010, and December 31, 2015. Interventions: Mild sepsis-associated coagulopathy was defined as an international normalized ratio greater than or equal to 1.2 and less than 1.4 plus platelet count less than or equal to 150,000/µL but greater than 100,000/µL; moderate sepsis-associated coagulopathy was defined with either an international normalized ratio greater than or equal to 1.4 but less than 1.6 or platelets less than or equal to 100,000/µL but greater than 80,000/µL; severe sepsis-associated coagulopathy was defined as an international normalized ratio greater than or equal to 1.6 and platelets less than or equal to 80,000/µL. Measurements and Main Results: Hospital mortality increased progressively from 25.4% in patients without sepsis-associated coagulopathy to 56.1% in patients with severe sepsis-associated coagulopathy. Similarly, duration of hospitalization and ICU care increased progressively as sepsis-associated coagulopathy severity increased. Multivariable analyses showed that the presence of sepsis-associated coagulopathy, as well as sepsis-associated coagulopathy severity, was independently associated with hospital mortality regardless of adjustments made for baseline patient characteristics, hospitalization variables, and the sepsis-associated coagulopathy-cancer interaction. Odds ratios ranged from 1.33 to 2.14 for the presence of sepsis-associated coagulopathy and from 1.18 to 1.51 for sepsis-associated coagulopathy severity for predicting hospital mortality (p

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Urgent Chemotherapy in Sepsis-Like Shock Related to Hematologic Malignancies

Objectives: Hematologic malignancies may result in multiple organ involvement including pulmonary and renal dysfunctions, and the less common acute circulatory failure. We herein addressed the outcome of patients with sepsis-like shock related to aggressive hematologic malignancies. Design: A 10-year (2007–2016) monocenter retrospective study. Settings: A medical ICU in a tertiary care center. Patients: Patients with circulatory shock requiring vasopressors and who subsequently received chemotherapy. Shock was presumably related to the underlying malignancy after ruling out an ongoing or new-onset infectious process. The extent and time course of organ failures was assessed by a modified Sequential Organ Failure Assessment score devoid of the platelet component. Interventions: None. Measurements and Main Results: Seventeen patients were included, including 13 with non-Hodgkin lymphoma, two with hyperleukocytic acute myeloid leukemia, and two with “Human Herpes virus 8”–associated multicentric Castleman’s disease. The following associated conditions prompted urgent administration of chemotherapy: tumor lysis syndrome (n = 10), hemophagocytic lymphohistiocytosis (n = 3), compressive bulky tumor (n = 3), pulmonary involvement (n = 3), and disseminated intravascular coagulation (n = 1). Following the initiation of chemotherapy, a number of patients died rapidly from untractable multiple organ failure. In contrast, chemotherapy led to a fast and dramatic improvement in organ failures in early survivors, as shown by the decrease in the modified Sequential Organ Failure Assessment score. However, the overall outcome was poor since only four and three patients could be discharged alive from the ICU and the hospital, and three and two patients remained alive at 6 months and 1 year. Conclusions: Multiple organ dysfunction syndrome related to hematologic malignancies is associated with a dismal outcome. A chemotherapy trial may provide a fast prognostic assessment of the reversibility of organ failure. Dr. Pène is the guarantor of the content of the article, including the data and analysis. Drs. Cherruault and Pène designed the study, collected the data, performed the analysis, and drafted the article. Drs. Goff and Tamburini collected the data, contributed to data interpretation and analysis, and revised the article for important intellectual content. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (http://ift.tt/29S62lw). Presented, in part, at the Congress “Réanimation 2017” of the French Intensive Care Society, Paris, France, January 11–13, 2017. The authors have disclosed that they do not have any potential conflicts of interest. For information regarding this article, E-mail: frederic.pene@aphp.fr Copyright © by 2018 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.

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Acute Kidney Injury and Subsequent Frailty Status in Survivors of Critical Illness: A Secondary Analysis

Objectives: Acute kidney injury frequently complicates critical illness and is associated with high morbidity and mortality. Frailty is common in critical illness survivors, but little is known about the impact of acute kidney injury. We examined the association of acute kidney injury and frailty within a year of hospital discharge in survivors of critical illness. Design: Secondary analysis of a prospective cohort study. Setting: Medical/surgical ICU of a U.S. tertiary care medical center. Patients: Three hundred seventeen participants with respiratory failure and/or shock. Interventions: None. Measurements and Main Results: Acute kidney injury was determined using Kidney Disease Improving Global Outcomes stages. Clinical frailty status was determined using the Clinical Frailty Scale at 3 and 12 months following discharge. Covariates included mean ICU Sequential Organ Failure Assessment score and Acute Physiology and Chronic Health Evaluation II score as well as baseline comorbidity (i.e., Charlson Comorbidity Index), kidney function, and Clinical Frailty Scale score. Of 317 patients, 243 (77%) had acute kidney injury and one in four patients with acute kidney injury was frail at baseline. In adjusted models, acute kidney injury stages 1, 2, and 3 were associated with higher frailty scores at 3 months (odds ratio, 1.92; 95% CI, 1.14–3.24; odds ratio, 2.40; 95% CI, 1.31–4.42; and odds ratio, 4.41; 95% CI, 2.20–8.82, respectively). At 12 months, a similar association of acute kidney injury stages 1, 2, and 3 and higher Clinical Frailty Scale score was noted (odds ratio, 1.87; 95% CI, 1.11–3.14; odds ratio, 1.81; 95% CI, 0.94–3.48; and odds ratio, 2.76; 95% CI, 1.34–5.66, respectively). In supplemental and sensitivity analyses, analogous patterns of association were observed. Conclusions: Acute kidney injury in survivors of critical illness predicted worse frailty status 3 and 12 months postdischarge. These findings have important implications on clinical decision making among acute kidney injury survivors and underscore the need to understand the drivers of frailty to improve patient-centered outcomes. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (http://ift.tt/29S62lw). Supported, in part, by National Institutes of Health grants K23DK090304 (to Dr. Abdel-Kader), the Vanderbilt Center for Kidney Disease (to Drs. Abdel-Kader and Siew), the Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury Study 5U01 DK082192-08 (to Dr. Siew), and the Veterans Affairs Health Services Research and Development IIR 13–073 (to Dr. Siew). Drs. Abdel-Kader, Girard, Brummel, Blume, Ely, Ikizler, and Pandharipande received support for article research from the National Institutes of Health (NIH). Dr. Girard’s institution received funding from the NIH. Dr. Ely’s institution received funding from the NIH and from Veterans Affairs funding, and he received funding from Orion, Abbott, and Pfizer. Dr. Bell’s institution received funding from the NIH-National Institute of Aging K23 career development award. Dr. Archer’s institution received funding from Patient-Centered Outcomes Research Institute and the Department of Defense and Pacira Pharmaceuticals, and received other support from the National Institute on Disability, Independent Living, and Rehabilitation Research, American Physical Therapy Association, and Brown University. Dr. Ikizler’s institution received funding from the National Institute of Diabetes and Digestive and Kidney Diseases. Dr. Siew received other support from Vanderbilt Center for Kidney Disease, and he disclosed work for hire. The remaining authors have disclosed that they do not have any potential conflicts of interest. For information regarding this article, E-mail: khaled.abdel-kader@vanderbilt.edu Copyright © by 2018 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.

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Predicting Survival in Patients Treated With Extracorporeal Membrane Oxygenation After Myocardial Infarction

Objectives: Acute myocardial infarction is the most common cause of cardiogenic shock. Although the number of patients with acute myocardial infarction complicated by cardiogenic shock who were treated with venoarterial extracorporeal membrane oxygenation increased during the last decade, detailed data on survival are lacking. We sought to analyze covariates that were independently associated with survival in this patient population and to externally validate the newly developed prEdictioN of Cardiogenic shock OUtcome foR Acute myocardial infarction patients salvaGed by venoarterial Extracorporeal membrane oxygenation (ENCOURAGE) score. Design: Retrospective clinical study. Setting: A single academic teaching hospital. Patients: Adult patients with acute myocardial infarction complicated by cardiogenic shock who were supported by venoarterial extracorporeal membrane oxygenation from June 2008 to September 2016. Interventions: Fourteen individual variables were assessed for their association with the primary endpoint. These variables were prespecified by the study team as being the most likely to affect survival. A receiver operating characteristic analysis was also performed to test the ability of the ENCOURAGE score to predict survival in this patient cohort. Measurements and Main Results: The primary endpoint of the study was in-hospital survival. A total of 61 patients were included in the analysis. Thirty-seven (60.7%) could be weaned from venoarterial extracorporeal membrane oxygenation and 36 (59.0%) survived. Survival was significantly higher in patients less than 65 years old (odds ratio, 14.6 [CI, 2.5–84.0]; p = 0.003), whose body mass index was less than 32 kg/m2 (odds ratio, 5.5 [CI, 1.2–25.4]; p = 0.029) and international normalized ratio was less than 2 (odds ratio, 7.3 [CI, 1.3–40.1]; p = 0.022). In patients where the first lactate drawn was less than 3 mmol/L, the survival was not significantly higher (odds ratio, 4.4 [CI, 0.6–32.6]; p = 0.147). The C-statistic for predicting survival using a modified version of the ENCOURAGE score, which replaced prothrombin activity less than 50% with an international normalized ratio greater than 2, was 0.73 (95% CI, 0.74–0.87). Conclusions: In this single-center study, several important covariates were associated with improved survival in patients with acute myocardial infarction complicated by cardiogenic shock who were supported by venoarterial extracorporeal membrane oxygenation and the ENCOURAGE score was found to be externally valid for predicting survival to hospital discharge. This work was performed at the Heart and Vascular Institute, Penn State Milton S. Hershey Medical Center, Hershey, PA. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (http://ift.tt/29S62lw). The authors have disclosed that they do not have any potential conflicts of interest. For information regarding this article, E-mail: dpabst@pennstatehealth.psu.edu Copyright © by 2018 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.

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Early Non-anticoagulant Desulfated Heparin After TBI: Reduced Brain Edema and Leukocyte Mobilization is Associated with Improved Watermaze Learning Ability Weeks After Injury

ABSTRACTBackgroundUnfractionated heparin (UFH) administered immediately after TBI reduces brain leukocyte (LEU) accumulation, and enhances early cognitive recovery, but may increase bleeding after injury. It is unknown how non-anticoagulant heparins such as 2,3-O desulfated heparin (ODSH), impact post-TBI cerebral inflammation and long term recovery. We hypothesized that ODSH after TBI reduces LEU-mediated brain inflammation and improves long term neurological recovery.MethodsCD1 male mice (n=66) underwent either TBI (controlled cortical impact; CCI) or sham craniotomy. ODSH [25mg/kg (25ODSH) or 50mg/kg (50ODSH)] or saline was administered for 48h after TBI in 46 animals. At 48h, intravital microscopy visualized rolling LEUs and fluorescent albumin leakage in the pial circulation, and the Garcia Neurological Test (GNT) assessed neurologic function. Brain edema (wet/dry ratio) was evaluated post-mortem. In a separate group of animals (n=20), learning/memory ability (% time swimming in the Probe platform quadrant) was assessed by the Morris Water Maze (MWM) 17 days after TBI. ANOVA with Bonferroni correction determined significance (p

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Site Variability in Regulatory Oversight for an International Study of Pediatric Sepsis

Objectives: Duplicative institutional review board/research ethics committee review for multicenter studies may impose administrative burdens and inefficiencies affecting study implementation and quality. Understanding variability in site-specific institutional review board/research ethics committee assessment and barriers to using a single review committee (an increasingly proposed solution) can inform a more efficient process. We provide needed data about the regulatory oversight process for the Sepsis PRevalence, OUtcomes, and Therapies multicenter point prevalence study. Design: Survey. Setting: Sites invited to participate in Sepsis PRevalence, OUtcomes, and Therapies. Subjects: Investigators at sites that expressed interest and/or participated in Sepsis PRevalence, OUtcomes, and Therapies. Interventions: None. Measurements and Main Results: Using an electronic survey, we collected data about 1) logistics of protocol submission, 2) institutional review board/research ethics committee requested modifications, and 3) use of a single institutional review board (for U.S. sites). We collected surveys from 104 of 167 sites (62%). Of the 97 sites that submitted the protocol for institutional review board/research ethics committee review, 34% conducted full board review, 54% expedited review, and 4% considered the study exempt. Time to institutional review board/research ethics committee approval required a median of 34 (range 3-186) days, which took longer at sites that required protocol modifications (median [interquartile range] 50 d [35–131 d] vs 32 d [14–54 d)]; p = 0.02). Enrollment was delayed at eight sites due to prolonged (> 50 d) time to approval. Of 49 U.S. sites, 43% considered using a single institutional review board, but only 18% utilized this option. Time to final approval for U.S. sites using the single institutional review board was 62 days (interquartile range, 34–70 d) compared with 34 days (interquartile range, 15–54 d) for nonsingle institutional review board sites (p = 0.16). Conclusions: Variability in regulatory oversight was evident for this minimal-risk observational research study, most notably in the category of type of review conducted. Duplicative review prolonged time to protocol approval at some sites. Use of a single institutional review board for U.S. sites was rare and did not improve efficiency of protocol approval. Suggestions for minimizing these challenges are provided. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (http://ift.tt/2gIrZ5Y). Supported, in part, by the Endowed Chair, Department of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine and the Center for Pediatric Clinical Effectiveness at The Children’s Hospital of Philadelphia. Financial support for data collection in all U.K. centers was provided by the U.K. National Institute of Health Research (NIHR) Clinical Research Network and in Southampton by the Southampton NIHR Wellcome Trust Clinical Research Facility. Dr. Michelson disclosed grant funding from the Patient-Centered Outcomes Research Institute (PCORI) and American Cancer Society (ACS), and she received funding from AstraZeneca (consultant on a data safety monitoring board (DSMB)). Dr. Weiss was supported by National Institute of General Medical Sciences (NIGMS) K23GM110496 and his institution received funding from the Center for Pediatric Clinical Effectiveness at The Children’s Hospital of Philadelphia, the National Institute of General Medical Sciences K23GM110496, ThermoFisher Scientific (honorarium for lecture), and Bristol-Meyers Squibb (honorarium for clinical trial advisory board), Dr. Fitzgerald’s institution received funding from the Children’s Hospital of Philadelphia Center for Pediatric Clinical Effectiveness. Dr. Ackerman received funding from ONY, Inc. (consultant, neonatology drug development). Dr. Thomas’ institution received funding from Gene Fluidics, and he received funding from Therabron and CareFusion. The remaining authors have disclosed that they do not have any potential conflicts of interest. ©2018The Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

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Πέμπτη 25 Ιανουαρίου 2018

Tri-Tech Forensics Announces Acquisition of Rescue Essentials

LELAND, N.C. and SALIDA, Colo. — Tri-Tech Forensics, Inc., a leader in the crime scene supplies, digital forensics, and evidence collection kit markets, announced today the acquisition of Rescue Essentials, a leading manufacturer and marketer of Individual First Aid Kits, tactical EMS supplies, and first responder trauma gear and equipment. Rescue Essentials’ products are sold to medical ...

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Accuracy of Computed Tomography in Diagnosis of Intra-abdominal Injuries in Stable Patients with Anterior Abdominal Stab Wounds: A Systematic Review and Meta-Analysis

Abstract

Background

Work-up for patients presenting to the Emergency Department (ED) following an anterior abdominal stab wound (AASW) has been debated since the 1960s. Experts agree that patients with peritonitis, evisceration, or hemodynamic instability should undergo immediate laparotomy (LAP), however, workup of stable, asymptomatic or non-peritoneal, patients is not clearly defined.

Objectives

To evaluate the accuracy of computed tomography of abdomen and pelvis (CTAP) for diagnosis of intra-abdominal injuries requiring Therapeutic Laparotomy (THER-LAP) in ED patients with AASW. Is a negative CT scan without a period of observation sufficient to safely discharge a hemodynamically stable, asymptomatic AASW patient?

Methods

We searched PUBMED, EMBASE, and Scopus from their inception until May 2017 for studies on ED patients with AASW. We defined the reference standard test as LAP for patients who were managed surgically and those with THER-LAP were considered as disease-positive. In those who were managed nonsurgically, inpatient observation was considered the reference standard. We used the Quality Assessment Tool for Diagnostic Accuracy Studies (QUADAS-2) to evaluate the risk of bias and applicability of the included studies. We attempted to compute the pooled sensitivity, specificity, Likelihood Ratios (LR+, LR-) using a random-effects model with MetaDiSc software and calculate testing and treatment thresholds for CT scan applying the Pauker and Kassirer model.

Results

Seven studies were included encompassing 575 patients. The weighted prevalence of THER-LAP was 34.3% (95% CI 30.5-38.2%). Studies had variable quality and the inclusion criteria were not uniform. The operating characteristics of CT scan were: sensitivity 50%-100%, specificity 39%-97%, LR+ 1.0-15.7 and LR- 0.07-1.0. The high heterogeneity (I-square>75%) of the operating characteristics of CT scan prevented pooling of the data and therefore the testing and treatment thresholds could not be estimated.

Discussion

The articles revealed a high prevalence (8.7%, 95% CI 6.1-12.2%) of injuries requiring THER-LAP in patients with a negative CT scan and almost half (47%, 95% CI 30-64%) of those injuries involved the small bowel.

Conclusions

In stable AASW patients, a negative CT scan alone without an observation period is inadequate to exclude significant intra-abdominal injuries.

This article is protected by copyright. All rights reserved.



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iPhone to get 911 location feature in update

Apple said they are adopting Advanced Mobile Location, a precise way for the phone to report the location of the caller to dispatchers

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7 Benefits of Implementing an Online Time Clock Into Your Time and Attendance Process

EMS agencies nationwide have started implementing biometric clocks into their time and attendance scheduling process based on the numerous benefits that come with the system. Biometric technology offers one of the most cost effective, convenient, and secure forms of employee and staff identification available in the world today; combining this tool with a strong EMS scheduling suite enables each agency ...

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Percutaneous cholecystostomy for severe (Tokyo 2013 stage III) acute cholecystitis

Abstract

Purposes

To evaluate the impact of percutaneous cholecystostomy (PC) on severe acute cholecystitis (AC).

Methods

According to the ICD-9 classification, we retrospectively retrieved medical records of patients discharged with a diagnosis of AC from January 2007 to December 2016 at our hospital. Patients were then stratified according to the Tokyo 2013 (TG 13) AC severity criteria. Grade III AC was diagnosed according to the TG 13 criteria. Indications for PC were failure of optimal medical treatment within 48 h, worsening of clinical condition within early medical treatment, patients unfit for upfront surgery and patient’s preference. Ascites was considered a contraindication to PC while coagulopathy was considered a minor contraindication. Primary end points were: clinical improvement, morbidity and related mortality. Secondary endpoints were AC recurrences and elective laparoscopic cholecystectomies (LS). Response was evaluated by clinical and blood test improvement. Morbidity was evaluated according to the Dindo–Clavien scale.

Results

A total of 117 eligible patients were diagnosed as grade III AC. Of these, 29 (24.7%) underwent PC. The procedure was completed in all cases. Overall morbidity rate was 20.6%. Main complication was the drainage dislodgement due to involuntary patient’s movement. Overall mortality was 17.2% but no causes of death were dependent upon the procedure. Clinical improvement was reported in 95.5% of surviving patients.

Conclusion

This study confirms that PC is a valuable tool in the treatment of severe AC. Randomized trials are needed to clarify the criteria for patient selection and to optimize the timing for both cholecystostomy and cholecystectomy.



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Smartwatch feedback device for high-quality chest compressions by a single rescuer during infant cardiac arrest: a randomized, controlled simulation study

Objective According to the guidelines, rescuers should provide chest compressions (CC) ∼1.5 inches (40 mm) for infants. Feedback devices could help rescuers perform CC with adequate rates (CCR) and depths (CCD). However, there is no CC feedback device for infant cardiopulmonary resuscitation (CPR). We suggest a smartwatch-based CC feedback application for infant CPR. Participants and methods We created a smartwatch-based CC feedback application. This application provides feedback on CCD and CCR by colour and text for infant CPR. To evaluate the application, 30 participants were divided randomly into two groups on the basis of whether CC was performed with or without the assistance of the smartwatch application. Both groups performed continuous CC-only CPR for 2 min on an infant mannequin placed on a firm table. We collected CC parameters from the mannequin, including the proportion of correct depth, CCR, CCD and the proportion of correct decompression depth. Results Demographics between the two groups were not significantly different. The median (interquartile range) proportion of correct depth was 99 (97–100) with feedback compared with 83 (58–97) without feedback (P=0.002). The CCR and proportion of correct decompression depth were not significantly different between the two groups (P=0.482 and 0.089). The CCD of the feedback group was significantly deeper than that of the control group [feedback vs. control: 41.2 (39.8–41.7) mm vs. 38.6 (36.1–39.6) mm; P=0.004]. Conclusion Rescuers who receive feedback of CC parameters from a smartwatch could perform adequate CC during infant CPR. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://ift.tt/1hexVwJ *Juncheol Lee and Yeongtak Song contributed equally to the writing of this article. Correspondence to Jaehoon Oh, MD, PhD, Department of Emergency Medicine, College of Medicine, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea Tel: +82 2 2290 8999; fax: +82 2 2290 9832; e-mail: ojjai@hanmail.net Received May 31, 2017 Accepted November 19, 2017 Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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A Review of the Landscape: Challenges and gaps in trauma response to civilian high threat mass casualty incidents.

The ultimate goal of the emergency response and trauma system is to reduce potentially preventable death from trauma. Tremendous advances in trauma care emerged from the past fifteen years of United States’ combat engagements around the globe. Unfortunately, combat and insurgency tactics have also metastasized to the civilian world, resulting in increasingly complex and dynamic acts of intentional mass violence. These high threat Active Violent Incidents (AVIs) pose significant preparedness, response and clinical care challenges to the civilian healthcare systems. Currently, there are several operational and policy gaps that limit the successful preparedness and response to AVIs and dynamic MCIs in the United States. Director, Operational and Disaster Medicine, Associate Professor, Emergency Medicine, Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, 1000 Blythe Blvd, Medical Education Building (MEB) 3, Charlotte, NC 28203, David.callaway@carolinashealthcare.org, (704) 355-3968 Conflicts of Interest and Source of Funding: Dr. David Callaway is a former voting member and current subject matter expert for the Committee on Tactical Combat Casualty Care, he is the Chair Emeritus of the Committee for Tactical Emergency Casualty Care, and he serves as the Co-Chair of the American College of Emergency Physicians High Threat Emergency Casualty Care Task Force. Dr. Callaway reports receiving an honoraria from Velico Medical. © 2018 Lippincott Williams & Wilkins, Inc.

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STAFF OFFICERS AS BLOOD SUPPLIERS: EFFECTS OF REPEATED DONATIONS AND AUTOLOGOUS REINFUSIONS OF UNTRANSFUSED UNITS

ABSTRACTBACKGROUNDLimited blood inventory and resupply chains in combat settings can result in preventable deaths from traumatic hemorrhage. One way of mitigating this could be to establish donor pools where blood is collected in advance of high-risk missions and then reinfused back to the donor if not needed to treat casualties.METHODS450+56 mL blood was collected, rested for 2 hours in room temperature and stored at 4 °C. The blood was reinfused 22-24 hours after donation and the donor observed for adverse reactions. Samples were collected before and 20 minutes after each donation for hematology, IgG, ferritin, CRP, total protein, LDH, bilirubin, haptoglobin and APTT.RESULTS9 participants went through a total of 36 donation and reinfusion procedures. 4 donors participated in 5 rounds, 2 in 4 rounds, 2 in 3 rounds, and 1 in 2 rounds. A significant drop was seen in hemoglobin (14.6 ± 0.9 to 13.9 ± 0.9) and ferritin (179 ± 70 to 149 ± 78) from before first donation to after the last reinfusion (p

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"The modified Veress Needle (mVN) for tension pneumothorax"

No abstract available

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The History and Promising Future of Phage Therapy in the Military Service

The continuous evolvement of bacterial resistance to most, if not all currently available antibiotics is a worldwide problem. These strains, frequently isolated from military-associated environments, have created an urgent need to develop supplementary anti-infective modalities. One of the leading directions is phage therapy, which includes the administration of bacteriophages, viruses that specifically target bacteria, as bio-therapies. Though neglected in the West until recent years, bacteriophages have been widely studied and clinically administered in the former Soviet Union and Eastern Europe for over a century, where they were found to be incredibly efficient at battling numerous infectious diseases. In this review, we will discuss the high potential of phage therapy as a solution for resistant bacterial infectious diseases relating to military medicine. By describing the historical development and knowledge acquired on phage therapy, we will define the advantages of bacteriophages for combating resistant bacteria in multiple settings, such as trauma injuries, foodborne illnesses, as a preventative tool and therapy against biological warfare agents, and more. We will also present the most recent successful clinical applications of bacteriophages in military settings worldwide. We believe that augmenting military medicine by integrating Phage Therapy is an important and required step in preparedness for the rapidly approaching post-antibiotic era. Corresponding Author: Ronen Hazan, PhD. Institute of Dental Sciences and School of Dental Medicine, Hebrew University, Hadassah Campus, Jerusalem P.O.B 12272, Israel 91120; Email: ronenh@ekmd.huji.ac.il, Phone: 972-2-6758588 Conflict of interest statement: The Authors do not have any conflict of interest. Meeting: This article was motivated by the poster presentation entitled “Bacteriophages vs Anthrax: Development of phage-based therapy against Bacillus anthracis infection” by Alkalay et al. presented in the 2017 MHSRS conference, Florida. © 2018 Lippincott Williams & Wilkins, Inc.

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Intra-Operative Combination of Resuscitative Endovascular Balloon Occlusion of the Aorta and a Median Sternotomy in Hemodynamically Unstable Patients' with Penetrating Chest Trauma: Is this feasible?

AbstractBackgroundRecent evidence suggests that REBOA is an effective live saving intervention in patients with severe torso trauma. However, the deployment of REBOA in patients with isolated penetrating intra-thoracic injuries remains controversial. We propose that a median sternotomy be performed in conjunction with REBOA as a feasible and effective means of hemorrhage control in patients suffering from penetrating chest trauma who present hemodynamically unstable. The objective of our study was to present our initial experience with this approach.MethodsA prospectively collected case series of the use of REBOA (10 Fr) in conjunction with a median sternotomy from January, 2015 to December, 2016 at a Level I Trauma Center. We included hemodynamically unstable non-compressible torso hemorrhage patients with penetrating chest trauma that underwent intra-operative REBOA deployment plus median sternotomy.ResultsA total of 68 trauma related emergent thoracic surgeries were performed at our institution during the study period. Of these, seven suffered from penetrating chest trauma and non-compressible torso hemorrhage and underwent REBOA plus median sternotomy. Six out of the seven patients suffered intra-thoracic vascular injuries: 2 subclavian arteries, 2 internal mammary arteries, 2 aortic arch and 5 major central venous injuries. Four patients had an associated lung injury with AIS>3, of which two suffered a pulmonary hilar vessel disruption. REBOA-related complications included one case of upper gastrointestinal bleeding. Six out of the seven patients survived the 30 day follow-up. No adverse neurologic outcomes or deficits were observed in survivors.ConclusionThe combined use of REBOA and median sternotomy could be a feasible and effective alternative to hemorrhage control in patients with non-compressible torso hemorrhage secondary to penetrating chest trauma. These findings challenge the recommendation against the use of REBOA in penetrating intra-thoracic injuries. Future studies with stronger designs and larger sample sizes are required to confirm our results.Level of EvidenceV, therapeutic Background Recent evidence suggests that REBOA is an effective live saving intervention in patients with severe torso trauma. However, the deployment of REBOA in patients with isolated penetrating intra-thoracic injuries remains controversial. We propose that a median sternotomy be performed in conjunction with REBOA as a feasible and effective means of hemorrhage control in patients suffering from penetrating chest trauma who present hemodynamically unstable. The objective of our study was to present our initial experience with this approach. Methods A prospectively collected case series of the use of REBOA (10 Fr) in conjunction with a median sternotomy from January, 2015 to December, 2016 at a Level I Trauma Center. We included hemodynamically unstable non-compressible torso hemorrhage patients with penetrating chest trauma that underwent intra-operative REBOA deployment plus median sternotomy. Results A total of 68 trauma related emergent thoracic surgeries were performed at our institution during the study period. Of these, seven suffered from penetrating chest trauma and non-compressible torso hemorrhage and underwent REBOA plus median sternotomy. Six out of the seven patients suffered intra-thoracic vascular injuries: 2 subclavian arteries, 2 internal mammary arteries, 2 aortic arch and 5 major central venous injuries. Four patients had an associated lung injury with AIS>3, of which two suffered a pulmonary hilar vessel disruption. REBOA-related complications included one case of upper gastrointestinal bleeding. Six out of the seven patients survived the 30 day follow-up. No adverse neurologic outcomes or deficits were observed in survivors. Conclusion The combined use of REBOA and median sternotomy could be a feasible and effective alternative to hemorrhage control in patients with non-compressible torso hemorrhage secondary to penetrating chest trauma. These findings challenge the recommendation against the use of REBOA in penetrating intra-thoracic injuries. Future studies with stronger designs and larger sample sizes are required to confirm our results. Level of Evidence V, therapeutic address correspondence to: Carlos A. Ordoñez MD FACS, ordonezcarlosa@gmail.com, Division of Trauma and Acute Care Surgery, Department of Surgery, Fundacion Valle del Lili and Universidad del Valle, Carrera 98 #18-49, Cali, Colombia. Conflict of interest: The authors have no conflict of interest, no disclosure. Financial Support: None Presented at the 76th Annual Meeting of AAST and Clinical Congress of Acute Care Surgery, September 13–16, 2017 in Baltimore, Maryland. © 2018 Lippincott Williams & Wilkins, Inc.

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Analysis of isolated transverse process fractures sustained during blast related events

AbstractBackgroundA range of devastating blast injuries have been sustained by personnel during recent conflicts. Previous studies have focused on severe injuries, including to the spine, however, no study has specifically focused on the most common spinal injury; transverse process (TP) fractures. Although their treatment usually requires limited intervention, analysis of TP fractures may help determine injury mechanisms.MethodsData was collected from victims with spinal fractures injured in Improvised Explosive Device (IED) attacks, from the UK’s Joint Theatre Trauma Registry. The level and side of each TP fracture was recorded, as well as associated injuries, whether they were mounted or dismounted, and outcome (survivor or fatality).ResultsThe majority of TP fractures were lumbar (80%). More bilateral (both left and right fractures at the same level), and L5 TP fractures, were seen in fatalities than survivors. In the mounted group, lumbar TP fractures were statistically significantly associated with fatality, head injury, non-compressible torso haemorrhage, pelvic injury, and other spinal injuries. In the dismounted group, thoracic TP fractures were associated with head, chest wall, and other spinal injuries, and lumbar TP fractures were associated with pelvic, and other spinal injuries.ConclusionsDifferent injury mechanisms of the TP in the mounted and dismounted groups are likely. Inertial forces acting within the torso due to rapid loading being transferred through the seat, or high intra-abdominal pressures causing the tensile forces acting through the lumbar fascia to avulse the TPs are likely mechanisms in the mounted group. Blunt trauma, violent lateral flexion-extension forces, or rapid flail of the lower extremities causing tension of the psoas muscle, avulsing the TP are likely causes in the dismounted group. Isolated lumbar TP fractures can be used as markers for more severe injuries, and fatality, in mounted blast casualties.Level of EvidencePrognostic and Epidemiological, Level III. Background A range of devastating blast injuries have been sustained by personnel during recent conflicts. Previous studies have focused on severe injuries, including to the spine, however, no study has specifically focused on the most common spinal injury; transverse process (TP) fractures. Although their treatment usually requires limited intervention, analysis of TP fractures may help determine injury mechanisms. Methods Data was collected from victims with spinal fractures injured in Improvised Explosive Device (IED) attacks, from the UK’s Joint Theatre Trauma Registry. The level and side of each TP fracture was recorded, as well as associated injuries, whether they were mounted or dismounted, and outcome (survivor or fatality). Results The majority of TP fractures were lumbar (80%). More bilateral (both left and right fractures at the same level), and L5 TP fractures, were seen in fatalities than survivors. In the mounted group, lumbar TP fractures were statistically significantly associated with fatality, head injury, non-compressible torso haemorrhage, pelvic injury, and other spinal injuries. In the dismounted group, thoracic TP fractures were associated with head, chest wall, and other spinal injuries, and lumbar TP fractures were associated with pelvic, and other spinal injuries. Conclusions Different injury mechanisms of the TP in the mounted and dismounted groups are likely. Inertial forces acting within the torso due to rapid loading being transferred through the seat, or high intra-abdominal pressures causing the tensile forces acting through the lumbar fascia to avulse the TPs are likely mechanisms in the mounted group. Blunt trauma, violent lateral flexion-extension forces, or rapid flail of the lower extremities causing tension of the psoas muscle, avulsing the TP are likely causes in the dismounted group. Isolated lumbar TP fractures can be used as markers for more severe injuries, and fatality, in mounted blast casualties. Level of Evidence Prognostic and Epidemiological, Level III. Corresponding author: Dr Nicolas Newell, Postdoctoral Research Fellow, Department of Bioengineering, Imperial College London, South Kensington Campus, London, SW7 2AZ, Tel: 07843895728, E-mail: n.newell09@imperial.ac.uk Conflict of Interest Statement: The authors declare no conflicts of interest. This paper is for consideration for the Military supplement. © 2018 Lippincott Williams & Wilkins, Inc.

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Permissive Hypotension vs. Conventional Resuscitation Strategies in Adult Trauma Patients with Hemorrhagic Shock: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Background Aggressive fluid resuscitation in trauma promotes deleterious effects such as clot disruption, dilutional coagulopathy and hypothermia. Animal studies suggest that permissive hypotension maintains appropriate organ perfusion, reduces bleeding and improves mortality. This review assesses the efficacy and safety of permissive hypotension in adult trauma patients with hemorrhagic shock. Methods We searched the MEDLINE and EMBASE databases from inception to May 2017 for randomized controlled trials comparing permissive hypotension vs. conventional resuscitation following traumatic injury. We included pre-operative and intraoperative resuscitation strategies. The primary outcome was 30-day or in-hospital mortality. Secondary outcomes included blood product utilization, estimated blood loss and in-hospital complications. Pooling was performed with a random-effects model. Results We screened 722 abstracts, from which five randomized trials evaluating 1158 patients were included. Blood pressure targets in the intervention arms varied from systolic BP 50 – 70 mmHg or MAP ≥ 50 mmHg as compared to systolic BP 65 – 100 mmHg or MAP ≥ 65 in the control arms. Two studies evaluated only patients with penetrating injury while the remaining three additionally included blunt injuries. Four trials suggested a survival benefit for 30-day or in-hospital mortality with hypotensive resuscitation, although three studies were insufficiently powered to find statistical significance. Studies were of poor to moderate quality due to poor protocol reporting and lack of blinding. The pooled odds ratio was 0.70 (95% CI 0.53 to 0.92), suggesting a survival benefit for permissive hypotension. Those patients received fewer blood products and had lesser estimated blood loss. Conclusion Permissive hypotension may offer a survival benefit over conventional resuscitation for patients with hemorrhagic injury. It may additionally reduce blood loss and blood product utilization. However, the majority of studies were underpowered, thus reflecting a need for high quality, adequately powered trials. Level of Evidence Systematic Review, Level II PROSPERO Registration CRD42017070526 Corresponding Author: Maher Matar, Division of General Surgery, the Ottawa Hospital, Ottawa, Canada, The Ottawa Hospital - Civic Campus, 1053 Carling Avenue CPC, Suite 330, Ottawa, ON, K1Y 4E9, Email: mmatar@toh.ca There are no funding disclosures or conflicts of interest to declare. This paper was not presented at any meetings. © 2018 Lippincott Williams & Wilkins, Inc.

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Avoiding Cribari gridlock: the Standardized Triage Assessment Tool improves the accuracy of the Cribari Matrix Method in identifying potential over- and undertriage

Background The Cribari matrix method (CMM) is the standard to identify potential over- and undertriage but requires case reviews to correct for the fact that Injury Severity Score does not account for physiology or comorbidities, nor is it well correlated with resource consumption. Further, the secondary reviews introduce undesirable subjectivity. This study assessed if the Standardized Triage Assessment Tool (STAT)—a combination of the CMM and the Need For Trauma Intervention—could more accurately determine over- and undertriage than the CMM alone. Methods The registry of an ACS verified Level I adult trauma center in Texas was queried for all new ED traumas 2013-2016 (n = 11,110). Binary logistic regressions were used to test the associations between the triage determinations of each metric against indicators of injury severity (risk factors, complications, and mortality) and resource consumption (number of procedures in three days and total length of stay). Results Both metrics were associated with the indicators of injury severity and resource consumption in the expected directions, but STAT had stronger or equivalent associations with all variables tested. Using the CMM, there was 50.4% overtriage and 9.1% undertriage. Using STAT, overtriage was reduced to 30.8% (relative reduction = 38.9%) and undertriage was reduced to 3.3% (relative reduction = 63.7%). Conclusions Using the CMM with secondary case reviews makes valid multi-institutional triage rate comparisons impossible because of the subjective and unstandardized nature of these reviews. STAT’s out-of-box triage determinations (i.e., without manual case review) outperformed CMM in almost every tested variable for both over- and undertriage. STAT, an automatic, standardized method offers significant improvements compared to the current subjective system. Further, by accounting for both anatomic injury severity and resource consumption, STAT may allow trauma centers to better allocate resources and predict patient needs with fewer cases requiring manual review. Level of Evidence diagnostic criteria, level II All authors may be reached at 3409 Worth Street, Suite C2.500, Dallas, Texas 75246 All authors declare no conflicts of interest exist. This manuscript was presented at the 76th Annual Meeting of the American Association for the Surgery of Trauma, September 13-16, 2017 in Baltimore, MD. © 2018 Lippincott Williams & Wilkins, Inc.

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Trauma Transitional Care Coordination: A Mature System at Work

Background We have previously demonstrated effectiveness of a Trauma Transitional Care Coordination Program (TTCC) in reducing 30-day readmission rates for trauma patients most at risk. With program maturation, we achieved improved readmission rates for specific patient populations. Methods TTCC is a nursing driven program that supports patients at high risk for 30-day readmission. TTCC interventions include calls to patients within 72 hours of discharge, complete medication reconciliation, coordination of medical appointments, and individualized problem solving. Account IDs were used to link TTCC patients with the Health Services Cost Review Commission (HSCRC) database to collect data on statewide unplanned 30-day readmissions. Results 475 patients were enrolled in the TTCC program from January 2014 to September 2016. Only 11% (n=50) of TTCC enrollees were privately insured, 60% had Medicaid (n=259), and 13% had Medicare (n=64). 73% had HSCRC severity of injury (SOI) ratings of 3 or 4 (maximum SOI = 4). The most common All Patient Refined Diagnosis Related Groups (APR-DRG) for participants were: lower extremity procedures (n=67, 14%); extensive abdominal/thoracic procedures (n=40, 8.4%); musculoskeletal procedures (n=37, 7.8%); complicated tracheostomy and upper extremity procedures (n=29 each, 6.1%); infectious disease complications (n=14, 2.9%); major chest/respiratory trauma, major small and large bowel procedures and vascular procedures (n=13 each, 2.7%). TTCC participants with lower extremity injury, complicated tracheostomy, and bowel procedures had 6-point (10% vs 16%, p=0.05), 11-point (13% vs 24%, p=0.05), and 16-point (11% vs 27%, p=0.05) reduction in 30-day readmission rates respectively compared to those without TTCC. Conclusion Targeted outpatient support for high-risk patients can decrease 30-day readmission rates. As our TTCC program matured, we reduced 30-day readmission in patients with lower extremity injury, complicated tracheostomy and bowel procedures. This represents over one million dollars savings for the hospital per year through quality based reimbursement. Level of Evidence Level III, Epidemiological Corresponding Author: Erin C. Hall MD MPH, MedStar Washington Hospital Center, Washington DC, erin.c.hall@medstar.net, Pager: 202-801-1340 There are no conflicts of interest to report. Presented at the 76th Annual Meeting of the American Association for the Surgery of Trauma, September 12th, 2017 in Baltimore MD © 2018 Lippincott Williams & Wilkins, Inc.

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“Temporary Ectopic Implantation for Salvaging Amputated Parts: A Systematic Review”

Background Temporary ectopic implantation is an option when handling severe crushing injuries to the distal extremities or other body parts. The surgical techniques applied in those cases and the patient outcomes have not been previously analyzed. Methods Extensive literature search was performed using PubMed, EMBASE, and Google Scholar to collect articles reporting outcomes of temporary ectopic implantation for salvaging amputated extremities or other body parts. Age and gender of patients, injured part, amputation level, surgical details and clinical outcomes were recorded. Results 22 articles encompassing 38 amputated cases met the inclusion criteria. The publication dates ranged from 1986 to 2016. Of the 38 cases, temporary ectopic implantation procedures were performed in 16 digit-cases, 10 hand-cases, 3 forearm-cases, 5 foot-cases, 1 penis-case, 1 testes-case and 2 scalp-cases. The ectopic implantation duration varied from 6 to 319 days. The ectopic implantation and following replantation of the amputated parts resulted in a survival rate of 81.6% and 100%, respectively. With different follow-up duration, most patients were found to have sensation restore in the tips of reconstructed extremities, and those reconstructed extremities were functionally useful in daily lives. The function of other replanted parts was also satisfactory. Conclusions Temporary ectopic implantation is a valuable technique for salvaging amputation cases resulted from severe crushing injuries. There is yet no consensus on the indications of this surgical technique. In the future practices, both success and failure cases should be recorded and analyzed to help us to optimize the surgical strategies and improve the patient outcomes. Level of Evidence Level IV Study Type systematic review Correspondence authors: Feng Zhang, MD, PhD, Department of Orthopedics, Zhongshan Hospital, Fudan University, No.180 Fenglin Road, Shanghai 200032, China, Joseph M. Still Burn and Reconstructive Center, 1850 Chadwick Drive, 4 West Jackson, Mississippi 39204, USA, Email: feng.zhang@burncenters.com Conflicts of Interest and Source of Funding: None declared. © 2018 Lippincott Williams & Wilkins, Inc.

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Maximizing geographical efficiency: An analysis of the configuration of Colorado’s trauma system

ABSTRACTBackgroundTrauma center designation in excess of need risks dilution of experience, reduction in research and training opportunities, and increased costs. The objective of this study was to evaluate the use of a novel data-driven approach (whole-system mathematical modelling of patient flow) to compare the configuration of an existing trauma system with a mathematically optimized design, using the State of Colorado as a case study.MethodsGeographical network analysis and multi-objective optimization. 105,448 patients injured in the State of Colorado between 2009 and 2013, who met the criteria for inclusion in the state mandated trauma registry maintained by the Colorado Department of Public Health & Environment were included. We used the Non-dominant Sorting Genetic Algorithm II (NSGA-II) to conduct a multi-objective optimization of possible trauma system configurations, with the objectives of minimizing total system access time, and the number of casualties who could not reach the desired level of care.ResultsModelling suggested that system configurations with high volume level I trauma centers could be mathematically optimized with two centers rather than the current three (with an estimated annual volume of 970-1,020 and 715-722 severely injured patients per year), 4-5 level II centers, and 12-13 level III centers. Configurations with moderate volume level I centers could be optimized with three such centers (with estimated institutional volumes of 439-502, 699-947, and 520-726 severely injured patients per year), 2-5 level II centers, and 8-10 level III centers.ConclusionsThe modelling suggested that the configuration of Colorado’s trauma system could be mathematically optimized with fewer trauma centers than currently designated. Consideration should be given to the role of optimization modelling to inform decisions about the ongoing efficiency of trauma systems. However, modelling on its own cannot guarantee improved patient outcome; thus the use of model results for decision-making should take into account wider contextual information.Level of EvidenceLevel IV, epidemiologicalStudy typeGeospatial analysis Background Trauma center designation in excess of need risks dilution of experience, reduction in research and training opportunities, and increased costs. The objective of this study was to evaluate the use of a novel data-driven approach (whole-system mathematical modelling of patient flow) to compare the configuration of an existing trauma system with a mathematically optimized design, using the State of Colorado as a case study. Methods Geographical network analysis and multi-objective optimization. 105,448 patients injured in the State of Colorado between 2009 and 2013, who met the criteria for inclusion in the state mandated trauma registry maintained by the Colorado Department of Public Health & Environment were included. We used the Non-dominant Sorting Genetic Algorithm II (NSGA-II) to conduct a multi-objective optimization of possible trauma system configurations, with the objectives of minimizing total system access time, and the number of casualties who could not reach the desired level of care. Results Modelling suggested that system configurations with high volume level I trauma centers could be mathematically optimized with two centers rather than the current three (with an estimated annual volume of 970-1,020 and 715-722 severely injured patients per year), 4-5 level II centers, and 12-13 level III centers. Configurations with moderate volume level I centers could be optimized with three such centers (with estimated institutional volumes of 439-502, 699-947, and 520-726 severely injured patients per year), 2-5 level II centers, and 8-10 level III centers. Conclusions The modelling suggested that the configuration of Colorado’s trauma system could be mathematically optimized with fewer trauma centers than currently designated. Consideration should be given to the role of optimization modelling to inform decisions about the ongoing efficiency of trauma systems. However, modelling on its own cannot guarantee improved patient outcome; thus the use of model results for decision-making should take into account wider contextual information. Level of Evidence Level IV, epidemiological Study type Geospatial analysis Correspondence to: Jan Jansen, Division of Acute Care Surgery, Department of Surgery, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, Alabama 35294-0016. Email: jan.jansen@abdn.ac.uk. Phone: (205) 975-3030 Conflicts of Interest: The authors declare no conflicts of interest. Source of Funding: This project did not receive specific funding. Disclosure: The Health Services Research Unit at the University of Aberdeen, UK, receives funding from the Chief Scientist Office of the Scottish Government Health and Social Care Directorates. The opinions expressed in this article are those of the authors alone. © 2018 Lippincott Williams & Wilkins, Inc.

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Fresh Whole Blood resuscitation does not exacerbate skeletal muscle edema and long-term functional deficit after ischemic injury and hemorrhagic shock

ABSTRACTBACKGROUNDHemorrhagic shock due to extremity vascular injuries is common in combat injuries. Fluid resuscitation is the standard treatment for severe hemorrhage. Tourniquets (TK) used for hemorrhage control cause ischemia-reperfusion (I/R) injury that induces edema formation in the injured muscle. Resuscitation fluids affect edema formation; however, its effect on long-term functional response remains unknown. The objectives of this study are 1) compare acute muscle damage; 2) determine long-term functional recovery of ischemic muscle, and 3) compare local and systemic inflammatory response including the expression of junctional proteins following early resuscitation with HextendTM (HEX) and Fresh Whole Blood (FWB) using a rodent model of combined hemorrhage and TK-induced limb I/R.METHODSAnesthetized Sprague-Dawley rats underwent 42.5% arterial hemorrhage, followed by 3 hours of TK application. Animals were either not resuscitated or resuscitated with HEX or FWB. Two time points were evaluated, 2 and 28 days. Plasma cytokine concentrations were determined at baseline and end resuscitation. At two days, edema formation, expression of junctional proteins, and tissue level cytokines concentrations were evaluated. At 28 days, in vivo muscle contractile properties were determined. At both time-points, routine histology was performed and graded using a semi-quantitative grading system.RESULTSAll animals developed hemorrhagic hypovolemia; the mortality rate was 100% in non-resuscitated rats. HEX resuscitation exacerbated muscle edema (~11%) and muscle strength deficit (~20%). FWB resuscitation presented edema and muscle strength akin to TK only. FWB resuscitation pup-regulated expression of junctional proteins including pro-angiogenic factors and dampened the inflammatory response.CONCLUSIONFWB resuscitation does not exacerbate either TK induced edema or muscle strength deficit. FWB resuscitation may reduce both acute and long-term morbidity associated with extremity trauma. To our knowledge, this is the first study to demonstrate the nature of the resuscitation fluid administered following hemorrhage impacts short- and long-term indices of I/R in skeletal muscle.LEVEL OF EVIDENCEN/A BACKGROUND Hemorrhagic shock due to extremity vascular injuries is common in combat injuries. Fluid resuscitation is the standard treatment for severe hemorrhage. Tourniquets (TK) used for hemorrhage control cause ischemia-reperfusion (I/R) injury that induces edema formation in the injured muscle. Resuscitation fluids affect edema formation; however, its effect on long-term functional response remains unknown. The objectives of this study are 1) compare acute muscle damage; 2) determine long-term functional recovery of ischemic muscle, and 3) compare local and systemic inflammatory response including the expression of junctional proteins following early resuscitation with HextendTM (HEX) and Fresh Whole Blood (FWB) using a rodent model of combined hemorrhage and TK-induced limb I/R. METHODS Anesthetized Sprague-Dawley rats underwent 42.5% arterial hemorrhage, followed by 3 hours of TK application. Animals were either not resuscitated or resuscitated with HEX or FWB. Two time points were evaluated, 2 and 28 days. Plasma cytokine concentrations were determined at baseline and end resuscitation. At two days, edema formation, expression of junctional proteins, and tissue level cytokines concentrations were evaluated. At 28 days, in vivo muscle contractile properties were determined. At both time-points, routine histology was performed and graded using a semi-quantitative grading system. RESULTS All animals developed hemorrhagic hypovolemia; the mortality rate was 100% in non-resuscitated rats. HEX resuscitation exacerbated muscle edema (~11%) and muscle strength deficit (~20%). FWB resuscitation presented edema and muscle strength akin to TK only. FWB resuscitation pup-regulated expression of junctional proteins including pro-angiogenic factors and dampened the inflammatory response. CONCLUSION FWB resuscitation does not exacerbate either TK induced edema or muscle strength deficit. FWB resuscitation may reduce both acute and long-term morbidity associated with extremity trauma. To our knowledge, this is the first study to demonstrate the nature of the resuscitation fluid administered following hemorrhage impacts short- and long-term indices of I/R in skeletal muscle. LEVEL OF EVIDENCE N/A *Corresponding Author: Thomas Walters, PhD, Extremity Trauma and Regenerative Medicine, Institute of Surgical Research, 3698 Chambers Pass, JBSA Ft Sam Houston, TX 78234-7767, United States of America, Telephone: (210)-539-2726; Fax: (210)-539-3877. E-mail: thomas.j.walters22.civ@mail.mil There are no conflicts of interest This work was funded by the Combat Casualty Care Research Program, U.S. Army Medical Research and Materiel Command. “The opinions or assertions contained herein are the private views of the author and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.” © 2018 Lippincott Williams & Wilkins, Inc.

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Functional Stability of the TEG 6s Hemostasis Analyzer under Stress

Background Viscoelastic measurements of coagulation provide much needed information, including guidance for triage and insight into bleeding disorders. The current clinical standards for these devices are the TEG 5000 and the ROTEM delta, but a new product, the TEG 6s, has recently come to market, designed to simplify the user experience, reduce the required blood volume, and conduct multiple assays simultaneously. This study compares the performance of these three devices and examines the resiliency of the TEG 6s under various stresses. Methods The variances of coagulation metrics obtained by the TEG 6s (prototype and production models), TEG 5000, and ROTEM delta were compared using manufacturer’s reagents and citrate-collected blood from healthy donors. Variability between devices was examined, and their performance under various motion and temperature stresses was compared by placing one unit on a linear or orbital shaker, in the cold, or in the heat while a counterpart remained stationary at room temperature. Results While most comparable parameters had low degrees of variance, there were small but significantly increased variances found in some ROTEM delta and TEG 5000 parameters versus comparable TEG 6s parameters. Orbital rotation of the TEG 6s had no effect on means of any parameter but resulted in increased variance of two parameters; but linear motion with sudden striking had no observed impact on results. Similarly, 7 days’ exposure to heat (45 °C) or cold (4 °C) only resulted in minor deviations within normal ranges of the TEG 6s. Discussion The TEG 6s provides several improvements over other coagulation analyzers: it is easier to use and robustly resilient against motion and temperature stresses. These features suggest that it may be capable of deployment not only in the clinical lab but also to a variety of austere settings. Level of Evidence Diagnostic test, Level III. All authors are affiliated with the United States Army Institute of Surgical Research, JBSA Fort Sam Houston, Texas, 78234 Correspondence: Michael Adam Meledeo, USAISR, 3650 Chambers Pass, Bldg 3610, JBSA Fort Sam Houston, TX 78234, Fax: (210) 539-6244, Phone: (210) 539-7748. E-mail: michael.a.meledeo.civ@mail.mil The authors have no conflicts of interest to declare. This manuscript was submitted to the Journal of Trauma Acute Care Surgery THOR Supplement. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. © 2018 Lippincott Williams & Wilkins, Inc.

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How has the Affordable Care Act changed outcomes in Emergency General Surgery?

Introduction Lack of insurance coverage increases complications and mortality from surgical procedures. The 2014 Affordable Care Act (ACA) Open Enrollment (OE) insured more Americans, but it is unknown if this improved outcomes from emergency general surgery (EGS) procedures. This study seeks to determine how ACA OE coverage changes outcomes in EGS. Methods This is a retrospective review using the Nationwide Inpatient Sample (NIS) database from 2012-2014. Patients aged 18-64 undergoing EGS procedures were identified by ICD-9 codes. Medicare patients were excluded. Patient demographics, hospital characteristics and Charlson Comorbidity Index (CCI) were obtained. Outcomes were measured by mortality, complications and calculated costs. Univariate and difference-in-differences (DID) multivariate analyses were performed to determine the effect of the ACA OE on EGS outcomes. Results 304,110 EGS cases were identified. After Medicare patients were excluded, there were 275,425 cases. In 2014 Medicaid (MCD) admissions increased 18.2% from 18,495 to 22,615 (p<.001 and self-pay admissions decreased from to mortality significantly increased for sp patients in did analysis indicated that after risk adjustment the aca oe was associated with a small reduction insured p=".034)," complications wage-index adjusted mean costs there significant increase medicare private insurance teaching hospitals while non-teaching had fewer egs greater uninsured admissions. conclusions created but not reduce mortality. indicating primarily lower-risk patients. cost saw majority of medicaid national registry would improve future study policy on outcomes. type economic level evidence iii. correspondence: jay doucet md division trauma surgical critical care burns acute surgery department university california san diego w. arbor drive. mc ca phone fax authors declare they have no conflicts interest regarding this work. work presented as podium presentation at annual meeting aast clinical congress surgery. september baltimore marriott waterfront md. received external funding. lippincott williams wilkins inc.>

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Abdominal Trauma Surgery During Recent U.S. Combat Operations from 2002-2016

Background Abdominal surgery constitutes approximately 13% of surgical procedures performed for combat injuries. This study examines the frequencies and type of abdominal surgical procedures performed during recent U.S. Military operations. Methods A retrospective analysis of the Department of Defense Trauma Registry (DoDTR) was performed for all Role 2 (R2) and Role 3 (R3) medical treatment facilities (MTFs), from January 2002 to May 2016. The 273 ICD-9-CM procedure codes that were identified as abdominal surgical procedures were stratified into 24 groups based on anatomic and functional classifications and then grouped by whether or not they were laparoscopic. Procedure grouping and categorization were determined, and adjudicated if necessary, by subject matter experts. Data analysis used Stata Version 14 (College Station, Texas). Results A total of 26,548 abdominal surgical procedures were identified at R2 and R3 MTFs. The majority of abdominal surgical procedures were reported at R3 facilities. The largest procedure group at both R2 and R3 MTFs were procedures involving the bowel. There were 18 laparoscopic procedures reported (R2:4 R3:14). Laparotomy Not Otherwise Specified was the second largest procedure group at both R2 (1,060, 24.55%) and R3 (4,935, 22.2%) MTFs. Abdominal caseload was variable over the 15 year study period. Conclusions Surgical skills such as open laparotomy and procedures involving the bowel are crucial in war surgery. The abundance of laparotomy NOS may reflect inadequate documentation, or the plethora of 2nd and 3rd look operations and washouts performed for complex abdominal injuries. Traditional elective general surgical cases (gallbladder, hernia) were relatively infrequent. Laparoscopy was almost nonexistent. Open abdominal surgical skills therefore remain a necessity for the deployed U.S. Military General Surgeons; this is at odds with the shifting paradigm from open to laparoscopic skills in stateside civilian and military hospitals. Level of Evidence Level III, Epidemiologic study Correspondence: Caryn Turner, MPH, Joint Trauma System, San Antonio Military Medical Center, 3698 Chambers Pass, Bldg. 3611, Ft. Sam Houston, Texas 78234-7767, Phone: 806-549-7821, Fax: 210-539-8215. Email: Caryn.A.Turner.ctr@mail.mil; Caryn.A.Turner@gmail.com Conflict of Interest: The authors declare no conflicts of interest. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army, Department of the Navy or the Department of Defense. Support and funding for this study was provided in part by an apportionment of one author (C.A.T) to the Research Participation Program for the U.S. Army Institute of Surgical Research, Joint Trauma System, administered by the Oak Ridge Institute for Science and Education through an agreement between the Department of Energy and the Department of Defense. Presentations: Poster: 2017 Military Health System Research Symposium: August 27-30, 2017 in Kissimmee, Florida. © 2018 Lippincott Williams & Wilkins, Inc.

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Effect of door-to-angioembolization time on mortality in pelvic fracture: every hour of delay counts

AbstractIntroductionAngioembolization (AE) is widely used for hemorrhagic control in patients with pelvic fracture. The latest version of the Resources for Optimal Care of theInjured Patient issued by the American College of Surgeons Committee on Trauma requires interventional radiologists to be available within 30 minutes to perform an emergent AE. However, the impact of time-to-AE on patient outcomes remains unknown. We hypothesized that a longer time-to-AE would be significantly associated with increased mortality in patients with pelvic fracture.MethodsThis is a 2-year retrospective cohort study using the American College of Surgeons Trauma Quality Improvement Program (ACS-TQIP) database from January 2013 to December 2014. We included adult patients (age ≥18 years) with blunt pelvic fracture who underwent pelvic AE within 4 hours of hospital admission. Patients who required any hemorrhage control surgery for associated injuries within 4 hours were excluded. Hierarchical logistic regression was performed to evaluate the impact of time-to-AE on in-hospital and 24-hour mortality.ResultsA total of 181 patients were included for analysis. The median age was 54 years (interquartile range [IQR]: 38-68) and 69.6% were male. The median ISS was 34 (IQR: 27-43). Overall in-hospital mortality rate was 21.0%. The median packed red blood cell transfusion within 4 and 24 hours after admission were 4 and 6 units, respectively. After adjusting for other covariates in a hierarchical logistic regression model, a longer time-to-pelvic AE was significantly associated with increased in-hospital mortality (odds ratio: 1.79 for each hour, 95% confidence interval: 1.11-2.91, p=0.018).ConclusionThe current study showed an increased risk of in-hospital mortality related to a prolonged time-to-AE for hemorrhagic control following pelvic fractures. Our results suggest that all trauma centers should allocate resources to minimize delays in performing pelvic AE.Level of EvidencePrognostic study, Level IV Introduction Angioembolization (AE) is widely used for hemorrhagic control in patients with pelvic fracture. The latest version of the Resources for Optimal Care of theInjured Patient issued by the American College of Surgeons Committee on Trauma requires interventional radiologists to be available within 30 minutes to perform an emergent AE. However, the impact of time-to-AE on patient outcomes remains unknown. We hypothesized that a longer time-to-AE would be significantly associated with increased mortality in patients with pelvic fracture. Methods This is a 2-year retrospective cohort study using the American College of Surgeons Trauma Quality Improvement Program (ACS-TQIP) database from January 2013 to December 2014. We included adult patients (age ≥18 years) with blunt pelvic fracture who underwent pelvic AE within 4 hours of hospital admission. Patients who required any hemorrhage control surgery for associated injuries within 4 hours were excluded. Hierarchical logistic regression was performed to evaluate the impact of time-to-AE on in-hospital and 24-hour mortality. Results A total of 181 patients were included for analysis. The median age was 54 years (interquartile range [IQR]: 38-68) and 69.6% were male. The median ISS was 34 (IQR: 27-43). Overall in-hospital mortality rate was 21.0%. The median packed red blood cell transfusion within 4 and 24 hours after admission were 4 and 6 units, respectively. After adjusting for other covariates in a hierarchical logistic regression model, a longer time-to-pelvic AE was significantly associated with increased in-hospital mortality (odds ratio: 1.79 for each hour, 95% confidence interval: 1.11-2.91, p=0.018). Conclusion The current study showed an increased risk of in-hospital mortality related to a prolonged time-to-AE for hemorrhagic control following pelvic fractures. Our results suggest that all trauma centers should allocate resources to minimize delays in performing pelvic AE. Level of Evidence Prognostic study, Level IV This paper was presented at 76th Annual Meeting of the American Association for Surgery of Trauma and Clinical Congress of Acute Care Surgery, September 15, 2017 Baltimore, Maryland All authors deny any potential conflicts of interest Neither internal nor external financial support was used for this study Corresponding Author: Kazuhide Matsushima, MD, Assistant Professor of Surgery, University of Southern California, LAC+USC Medical Center, 2051 Marengo Street, Inpatient Tower (C), C5L100, Los Angeles, CA 90033, Tel: 323-409-8597, Fax: 323-441-9907. E-mail: kazuhide.matsushima@med.usc.edu © 2018 Lippincott Williams & Wilkins, Inc.

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Implementation of a National Trauma Research Action Plan (NTRAP)

Summary Abstract Traumatic injury is a significant public health problem and the leading cause of death under age 44 in the United States. Federal investment in research funding is needed to address this issue and minimize death and disability. This report seeks to lay out a strategy for the development and implementation of a National Trauma Research Action Plan as described in the 2016 report by the National Academies of Sciences, Engineering, and Medicine (NASEM) entitled, Integrating Military and Civilian Trauma Systems to Achieve Zero Preventable Deaths after Injury. The authors have no Conflict of Interest to declare relevant to this work. While there was no direct funding for this manuscript, the April 2017 stakeholder conference discussed was supported by a grant from the National Highway Transportation Safety Administration and the Department of Defense. © 2018 Lippincott Williams & Wilkins, Inc.

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Development and External Validation of an Automated Computer-Aided Risk Score for Predicting Sepsis in Emergency Medical Admissions Using the Patient’s First Electronically Recorded Vital Signs and Blood Test Results

Objectives: To develop a logistic regression model to predict the risk of sepsis following emergency medical admission using the patient’s first, routinely collected, electronically recorded vital signs and blood test results and to validate this novel computer-aided risk of sepsis model, using data from another hospital. Design: Cross-sectional model development and external validation study reporting the C-statistic based on a validated optimized algorithm to identify sepsis and severe sepsis (including septic shock) from administrative hospital databases using International Classification of Diseases, 10th Edition, codes. Setting: Two acute hospitals (York Hospital - development data; Northern Lincolnshire and Goole Hospital - external validation data). Patients: Adult emergency medical admissions discharged over a 24-month period with vital signs and blood test results recorded at admission. Interventions: None. Main Results: The prevalence of sepsis and severe sepsis was lower in York Hospital (18.5% = 4,861/2,6247; 5.3% = 1,387/2,6247) than Northern Lincolnshire and Goole Hospital (25.1% = 7,773/30,996; 9.2% = 2,864/30,996). The mortality for sepsis (York Hospital: 14.5% = 704/4,861; Northern Lincolnshire and Goole Hospital: 11.6% = 899/7,773) was lower than the mortality for severe sepsis (York Hospital: 29.0% = 402/1,387; Northern Lincolnshire and Goole Hospital: 21.4% = 612/2,864). The C-statistic for computer-aided risk of sepsis in York Hospital (all sepsis 0.78; sepsis: 0.73; severe sepsis: 0.80) was similar in an external hospital setting (Northern Lincolnshire and Goole Hospital: all sepsis 0.79; sepsis: 0.70; severe sepsis: 0.81). A cutoff value of 0.2 gives reasonable performance. Conclusions: We have developed a novel, externally validated computer-aided risk of sepsis, with reasonably good performance for estimating the risk of sepsis for emergency medical admissions using the patient’s first, electronically recorded, vital signs and blood tests results. Since computer-aided risk of sepsis places no additional data collection burden on clinicians and is automated, it may now be carefully introduced and evaluated in hospitals with sufficient informatics infrastructure. Drs. Richardson and Mohammed had the original idea for this work. Dr. Faisal, Mr. Scally, and Dr. Mohammed undertook the statistical analyses. Mr. Beatson and Howes extracted the necessary data frames. Dr. Richardson gave a clinical perspective. Drs. Faisal and Mohammed wrote the first draft of this article, and all authors subsequently assisted in redrafting and have approved the final version. Dr. Mohammed will act as guarantor. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (http://ift.tt/29S62lw). Supported, in part, funded by the Health Foundation. The Health Foundation is an independent charity working to improve the quality of healthcare in the United Kingdom. This research was supported by the National Institute for Health Research (NIHR) Yorkshire and Humber Patient Safety Translational Research Centre (NIHR Yorkshire and Humber PSTRC). The views expressed in this article are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health. All authors’ institutions received funding from the Health Foundation. Mr. Scally and Speed received support for article research from the Health Foundation. For information regarding this article, E-mail: M.A.Mohammed5@Bradford.ac.uk Copyright © by 2018 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.

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Initiating Nutritional Support Before 72 Hours Is Associated With Favorable Outcome After Severe Traumatic Brain Injury in Children: A Secondary Analysis of a Randomized, Controlled Trial of Therapeutic Hypothermia

Objectives: To understand the relationship between the timing of initiation of nutritional support in children with severe traumatic brain injury and outcomes. Design: Secondary analysis of a randomized, controlled trial of therapeutic hypothermia (Pediatric Traumatic Brain Injury Consortium: Hypothermia, also known as “the Cool Kids Trial” (NCT 00222742). Settings: Fifteen clinical sites in the United States, Australia, and New Zealand. Subjects: Inclusion criteria included 1) age less than 18 years, 2) postresuscitation Glasgow Coma Scale less than or equal to 8, 3) Glasgow Coma Scale motor score less than 6, and 4) available to be randomized within 6 hours after injury. Exclusion criteria included normal head CT, Glasgow Coma Scale equals to 3, hypotension for greater than 10 minutes ( 30 min), pregnancy, penetrating injury, and unavailability of a parent or guardian to consent at centers without emergency waiver of consent. Interventions: Therapeutic hypothermia (32–33°C for 48 hr) followed by slow rewarming for the primary study. For this analysis, the only intervention was the extraction of data regarding nutritional support from the existing database. Measurements and Main Results: Timing of initiation of nutritional support was determined and patients stratified into four groups (group 1—no nutritional support over first 7 d; group 2—nutritional support initiated

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