Persistent injury-associated anemia and aging: novel insights

AbstractBackgroundHypercatecholaminemia and bone marrow dysfunction have been implicated in the pathophysiology of persistent-injury associated anemia. The elderly may be more vulnerable to bone marrow dysfunction due to high basal and peak catecholamine levels and impaired hematopoietic progenitor growth. We hypothesized that aging would adversely affect persistent injury-associated anemia.MethodsMale Sprague Dawley rats age 8-9 weeks and F344-BN rats age 25 months were randomized to: naïve controls, lung contusion plus hemorrhagic shock (LCHS), and LCHS plus daily chronic restraint stress (LCHS/CS). Urine norepinephrine was measured on days one and seven. Mobilization of hematopoietic progenitor cells (HPC), bone marrow colony forming units-erythroid (CFU-E) growth, and peripheral blood hemoglobin, mean corpuscular volume (MCV), and red cell distribution width (RDW) were assessed on day seven. **p

from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2CaRfvC