Introduction: Trauma pneumonectomy has been historically associated with an exceedingly high morbidity and mortality. The recent advent of standardized reporting and data-collecting measures has facilitated large volume data-analysis on predictors and outcomes of trauma pneumonectomy. The purpose of this study is to describe patient characteristics and outcomes of the patients who underwent trauma pneumonectomy in the modern era and identify clinical factors associated with postoperative mortality. Methods: Data between 2007 and 2014 from the National Trauma Data Bank was used for analysis, which included patients with both blunt and penetrating trauma who underwent pneumonectomy within 24 hours after admission. Patient characteristics, injury data, and outcomes were analyzed. Postoperative survival was estimated using the Kaplan-Meier method. Multivariate logistic regression analysis was performed to identify variables associated with postoperative mortality. Results: A total of 261 patients were included for analysis. Of those, 163 patients (62.5%) sustained penetrating trauma. Less invasive lung resections were performed prior to pneumonectomy in 12.6% of patients. First 24-hour and in-hospital mortality were significantly higher in blunt trauma patients compared to penetrating trauma patients (54.1% vs. 34.1% and 77.6% vs. 49.1%, respectively; p
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