Background: Hypoperfusion is associated with hyperfibrinolysis and early death from exsanguination, while tissue trauma is associated with hypofibrinolysis and delayed death from organ failure. We sought to elucidate the effects of injury patterns on fibrinolysis phenotypes using a non-human primate (NHP) model. Methods: NHPs were randomized to three injury groups (n=8/group): 60 min severe pressure-targeted controlled hemorrhagic shock (HS); HS + soft tissue injury (HS+); or HS + soft tissue injury + femur fracture (HS++). Animals were resuscitated and monitored for 360 min. Blood samples were collected at baseline (BSLN), end-of-shock (EOS), end-of-resuscitation (EOR), and T=360 min for assessments of: severity of shock (lactate) and coagulation via prothrombin time (PT), partial thromboplastin time (PTT), D-dimer, fibrinogen, anti-thrombin-III (AT-III), von Willebrand factor (vWF); and viscoelastic testing (ROTEM(R)). Results are reported as mean+/-SEM; statistics: two-way ANOVA and t-tests; significance: p
from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2kus661
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Oral Candida colonization in xerostomic post‐radiotherapy head and neck cancer patients 16h ... Oral Candida colonization in xerostomic post...
-
U.S. Department of Veterans Affairs Research News from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2iVEnBB
-
Clinical application of stress echocardiography for valvular heart disease Abstract Stress echocardiography is widely used to assess several...
-
MedStar replaced training diagrams with drone flyovers of the driving course to better demonstrate how to navigate a complicated driving sc...
-
Hard to believe, but there was a time we were without the most necessary EMS tools. That all changed, thanks to these creative minds. fro...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου