Objectives: To determine if there is a difference between regional citrate and global heparinized anticoagulation on circuit lifetimes during continuous venovenous hemodialysis in children. Design: Prospective "cross-over" trial. Setting: PICU, Department of Pediatrics, University Hospital Ostrava. Patients: Children 0-18 years old. Interventions: From 2009 to 2014, 63 eligible children (age, 89.24 +/- 62.9 mo; weight, 30.37 +/- 20.62 kg) received at least 24 hours of continuous venovenous hemodialysis. Each child received four continuous venovenous hemodialysis circuits with anticoagulants in the following order: heparin, citrate, heparin, citrate. Circuit life ended when transmembrane pressure was greater than or equal to 250 mm Hg for more than 60 minutes. Measurements and Main results: The total mean circuit lifetime was 39.75 +/- 10.73 hours. Citrate had a significantly longer median circuit lifetime (41.0 hr; CI, 37.6-44.4) than heparin (36.0 hr; CI, 35.4-36.6; p = 0.0001). Mortality was 33.33%. Circuit lifetime was significantly correlated to patient age (r = 0.606), weight (r = 0.763), and blood flow rate (r = 0.697). Transfusion rates (units of red cells per circuit of continuous venovenous hemodialysis) were 0.17 (0.0-1.0) with citrate and 0.36 (0.0-2.0) with heparin (p = 0.002). Conclusions: We showed in our study that citrate provided significantly longer circuit lifetimes than heparin for continuous venovenous hemodialysis in children. Citrate was superior to heparin for the transfusion requirements. Citrate was feasible and safe in children and infants. (C)2016The Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/29RW8xF
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Publication date: Available online 7 July 2018 Source: The Journal of Emergency Medicine Author(s): Audrey Uong, Ariel Brandwein, Colin C...
-
Abstract Malignant brain tumors are rapidly progressive and often fatal owing to resistance to therapies and based on their complex biolog...
-
Abstract Background Bone flap resorption (BFR) is the most prevalent complication resulting in autologous cranioplasty failure, but no c...
-
Injury from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1ULgTKC
-
Abstract Non-tumoral portal vein thrombosis (PVT) remains a highly relevant topic in the field of hepatology and liver transplantation wit...
-
Oral Candida colonization in xerostomic post‐radiotherapy head and neck cancer patients 16h ... Oral Candida colonization in xerostomic post...
-
Abstract Objectives Tumor invasion into blood and/or lymphatic vessels, perineural invasion, and histopathological grading are evaluated...
-
Abstract Many methods exist for generating keyframe summaries of videos. However, relatively few methods consider on-line summarisation, w...
-
Abstract Introduction Identifying occurrences of medication side effects and adverse drug events (ADEs) is an important and challenging ...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου