Background: While the relationship between underage drinking and injury has been well established, few studies have examined whether presenting for an acute injury moderates the efficacy of a brief intervention (BI) on alcohol misuse. Method: Patients (aged 14-20) in the emergency department screening positive for risky drinking (AUDIT-C score) completed a baseline assessment, were randomized to conditions [a stand-alone computer-delivered BI (n=277), a therapist-delivered BI (n=278), or a control condition (n=281)], and completed a 3-month follow-up. This secondary analysis of Project U connect examined regression models (controlling for baseline values) to examine the main effects of injury, and the interaction effects of injury by BI condition, on alcohol consumption and consequences. Results: Among 836 youth enrolled in the randomized controlled trial (mean age = 18.6, 51.6% male, 79.4% Caucasian), 303 (36.2%) had a primary complaint of intentional or unintentional injury. At baseline, injured patients were more likely to be male (p
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